肺癌患者血清leptin、AAG及α_1AT检测的临床意义  

The Clinical Value of Measurement of Serum Leptin,α_1-Acid Glycoprotein and Alphal-Antitrypsine Levels in Patients with Lung Cancer

作　　者：胡兴荣[1] 邓子辉[1] 薛辉[1] 颜光涛[1] 

机构地区：[1]解放军总医院基础医学研究所生物化学研究室,100853

出　　处：《放射免疫学杂志》2010年第4期363-365,共3页Journal of Radioimmanology

基　　金：国家自然科学基金面上项目(编号:30670821)

摘　　要：目的:探讨瘦素(leptin),α1-酸性糖蛋白(AAG)及α1-抗胰蛋白酶(α1AT)在肺癌患者血清中的变换规律,为临床早期诊断及肿瘤进展的判断提供依据。方法:收集我院确诊肺癌患者89例,健康体检者60例,分离血清后,放射免疫分析(RIA)检测血清leptin水平,酶联免疫吸附法(ELISA)检测AAG及α1AT水平。结果:肺癌组leptin、AAG及α1AT水平均显著高于正常对照组(P均<0.01),相关分析发现它们并无直接相关性。结论:肺癌患者血清中存在高水平的leptin、AAG及α1AT;它们之间并无直接相关性,在肺癌的发生、发展中各自独立发挥作用;血清leptin、AAG及α1AT检测对肺癌患者诊断、治疗有一定价值。Objective To investigate the early diagnostic value of measurement of changes of serum leptin,α1-acid glycoprotein（AAG）and alphal-antitrypsine（α1AT）levels in patients with lung cancer.Methods Serum leptin（with RIA）and serum AAG and α1AT（with ELISA）levels were determined in 89 patients with lung cancer and 60 controls.Results The serum levels of leptin,AAG and α1AT in patients with lung cancer were significantly higher than those in the controls.No correlations among the investigated serum parameters were demonstrated.Conclusion Serum leptin,AAG and α1AT levels are higher in patients with lung cancer.They may play inde-pendent roles in the development of lung cancer.Detection of the serum concentrations of leptin,AAG and α1AT is valuable for early diagnosis of lung cancer.

关 键 词：肺癌 瘦素 Α1-酸性糖蛋白 Α1-抗胰蛋白酶 

分 类 号：R692.5[医药卫生—泌尿科学]