唇软珊瑚胆甾烷的抗炎作用  

ANTI-INFLAMMATION ACTIONS OF SOFT CORAL CHOLESTANE

作　　者：王正濂[1] 许实波[1] 刘清[2] 李瑞声[2] 

机构地区：[1]中山大学生命科学院药学系,广州510275 [2]中山大学化学系,广州510275

出　　处：《热带海洋》1999年第2期27-32,共6页

摘　　要：从中国南沙群岛附近海域采集的唇软珊瑚提取的新结构化合物──唇软珊瑚胆甾烷（24－亚甲基－3β，5α，6β，19－四羟基－5α－胆甾烷）对二甲苯致小鼠耳肿胀、醋酸介导小鼠的毛细血管通透性、鸡蛋清所致大鼠足肿胀、大鼠棉球肉芽肿等炎症有显著抑制作用。抗炎机制研究表明：唇软珊瑚胆甾烷能显著抑制大鼠炎症足中致炎因子前列腺素E_2（PGE_2）和组胺的生成，同时对炎症足中的丙二醛的生成也有抑制作用。外源性花生四烯酸可完全桔抗唇软珊瑚胆甾烷对小鼠炎症足中丙二醛生成的抑制作用。A soft coral cholestane (24-methylene-3β,5α, 6β, 19-tetrahydroxy-5α-cholestane, MTC) was isolated from Chinese soft coral Nephthea brassica collectedfrom the South China Sea. It exhibited obvious inhibition on swelling of murine earsinduced by zylene, swelling of rat hind paws induced by egg white, blood capillarypermeability of mice induced by acetic acid, granuloma of rats induced by cotton. Thestudy on anti-inflammation mechanism indicated that MTC could inhibit the release ofinflammation factors such as PGE_2, histamine in inflammatory feet of rats as well asthe production of malonaldehyde (MDA) in inflammatory feet of mice. The inhibitionof MTC on the production of MDA in the inflammatory feet of mice could beantagonised completely by extrinsic arachidonic acid.

关 键 词：唇软珊瑚 胆甾烷 致炎因子 抗炎作用 抗炎机制 

分 类 号：R965[医药卫生—药理学] R931.74[医药卫生—药学]