幼年系统性红斑狼疮神经精神症候群的临床研究  

Clinical Study of Neuro-psychiatric Syndromes of Juvenile Systemic Lupus Erythematosus

作　　者：陈亚非[1] 阳林俊[1] 周银霞[1] 

机构地区：[1]解放军169医院门诊部,湖南衡阳421002

出　　处：《医学临床研究》2010年第9期1699-1701,共3页Journal of Clinical Research

摘　　要：[目的]探讨幼年系统性红斑狼疮（JSLE）神经系统表现的临床特征.[方法]选择本院风湿科1999年1月至2007年1月JSLE患者47例的临床资料作回顾性分析,分析其神经系统表现的临床特征.[结果]神经精神症候群29例（61.7%）,癫痫发作17例（36.2%）,狼疮性头痛7例（14.9%）,情绪失调5例（10.6%）,脑血管病4例（8.5%）,急性精神错乱3例（6.4%）,无菌性脑膜炎3例（6.4%）,精神障碍3例（6.4%）,运动障碍3例（6.4%）,格林-巴利综合征2例（4.3%）,颅神经病变1例（2.1%）.系统性红斑狼疮疾病活动指数（SLEDAL）和系统性红斑狼疮损伤指数（SLICC）与无神经表现的JSLE患者相比,差异有显著性（P〈0.05）.[结论]幼年系统性红斑狼疮病人的神经精神症候群普遍高发.[Objective]To explore the clinical features of neurological involvement in juvenile systemic lupus erythematosus（JSLE）. [Methods]The clinical data of 47 patients with JSLE in the department of rheumatology in our hospital from January 1999 to January 2007 were studied retrospectively. The clinical features of neurological involvement were analyzed. [Results] Neuro psychiatric syndromes were found in 29 cases （61.7%） including seizures in 17（36.2%）, intractable headache in 7（14.9%） and mood disorders in 5（10. 6%）. Cerebrovascular disease was found in 4（8.5%） ,acute confusional state in 3 （6.4%）, asepticmeningitis in 3（6.4%）, psychosis in 3（6.4%）, chorea in 3（6.4%）, Guillain-Barre syndrome in 2（4. 3%） and cranial neuropathy in 1（2.1%）. There was significant difference in systemic lupus erythematosus disease activity index （SLEDAL） and systemic lupus erythematosus damage index （SLICC） between JSLE patients with and without neurological manifestations. [Conelusion]Neuro psychiatric syndromes are frequent in JSLE patients.

关 键 词：红斑狼疮 系统性/并发症 神经症性障碍/病因学 

分 类 号：R593.24[医药卫生—内科学]