SLC11A1基因作用机制及其与结核病易患性的研究  

SLC11A1 gene mechanism and its relationship with susceptibility to tuberculosis

作　　者：吴喜蓉(综述)[1] 申阿东(审校)[1] 

机构地区：[1]首都医科大学附属北京儿童医院北京市儿科研究所中心实验室,100045

出　　处：《国际儿科学杂志》2010年第5期499-502,共4页International Journal of Pediatrics

基　　金：国家自然科学基金资助项目（30672258）

摘　　要：结核病是单一感染因素引起死亡人数最多的一种传染病.随着对结核病发病机制的深入研究,人们发现SLC11A1基因与结核病易患性有明显的相关性,其位于吞噬溶酶体膜上,通过改变细胞内环境,从而影响结核病的发生和发展.该文就SLC11M1基因作用机制及其与结核病易患性研究现状作一综述.Tuberculosis is the leading cause of death due to infection from a single microbial agent. With indepth study of the pathogenesis of tuberculosis,it was found that solute carrier family 11 member I gene SLC11A1） was ignificantly associated with susceptibility to tuberculosis. SLC11A1 is located in phagocytic lysosome membrane,influencing the occurrence and development of tuberculosis by changing the intracellular environment. In this paper, the mechanism of SLC11A1 gene and its relationwith susceptibility to tuberculosis are reviewed.

关 键 词：SLC11A1基因 结核病 易患性 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]