p38 MAPK信号转导通路与椎间盘退变  

p38 MAPK Signaling Pathway and Disc Degeneration(review)

作　　者：文天用[1] 李放[1] 叶超群[1] 

机构地区：[1]北京军区总医院骨科,北京市100700

出　　处：《中国康复理论与实践》2010年第9期841-842,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京市自然科学基金资助项目(5062039)

摘　　要：p38 MAPK信号通路是丝裂原活化蛋白激酶(MAPK)介导的信号转导通路的重要分支,它在炎症、细胞应激、凋亡、细胞周期和生长等多种生理和病理过程中起重要作用。既往在骨关节炎的研究中发现,p38参与炎性因子的激活、软骨细胞的凋亡等,与骨关节炎的病理过程密切相关。椎间盘退变也存在炎性反应、细胞凋亡等病理变化,这其中p38MAPK信号转导通路发挥的作用尚不明确。现将既往此类文献加以综述。p38 signaling pathway is an important branch of mitogen-activated protein kinase（MAPK）-mediated signal transduction pathway.It plays pivotal roles in various physiological and pathological events,such as inflammation,cell stress,apoptosis,cell cycle and growth.Previous research in osteoarthritis,p38 participation was found in the inflammatory factors activate,cartilage cell apoptosis etc.Disc degeneration,also associated with inflammatory response,apoptosis and pathological changes which p38 MAPK signaling pathways role is not clear.Some reports about this area are reviewed in this article.

关 键 词：P38 丝裂原活化蛋白激酶 椎间盘退变 综述 

分 类 号：R681.5[医药卫生—骨科学]