慢性乙型肝炎患者血清NO、iNOS和ALT含量变化及意义  

Significance of Serum Levels of NO,iNOS and ALT in Chronic Hepatitis B Patients

作　　者：张华欣[1] 彭俊华[1] 齐心亮[1] 朱发仁[1] 赵勇[1] 

机构地区：[1]兰州军区兰州总医院检验科,甘肃兰州730050

出　　处：《甘肃科学学报》2010年第3期72-74,共3页Journal of Gansu Sciences

摘　　要：探讨慢性乙型肝炎(CHB)患者血清一氧化氮(NO)、诱导型一氧化氮合酶(iNOS)和丙氨酸氨基转移酶(ALT)的水平变化及意义.CHB患者分为轻度(n=75)、中度(n=78)、重度(n=49)3组,以健康人群(n=74)为对照组,用生化方法检测血清中NOi、NOS和ALT水平.CHB患者血清NO和iNOS水平明显高于对照组.与对照组比较,轻、中度CHB患者的血清中NOi、NOS水平显著升高,ALT明显增高,NO含量与ALT水平呈正相关.重度CHB血清中白蛋白明显降低,但NO、iNOS水平无明显改变.NOi、NOS和ALT在CHB演变过程中发挥重要作用,其水平变化可作为评估慢性乙肝病情程度一项参考指标.To investigate the clinical significance of serum levels of nitric oxide（NO）,inducible nitric oxide synthase（iNOS） and alanine aminotransferase（ALT） in chronic hepatitis B（CHB） patients.The CHB patients were divided into mild（n=75）,moderate（n=78） and severe（n=49） groups,the control group is from the healthy people（n=74）.NO,iNOS and ALT were detected by biochemistry method.The levels of NO and iNOS were significantly increased in CHB patients than that in control group.Compared with control group,the levels of NO and iNOS were significantly increased in mild and moderate CHB patients too,ALT increased significantly,the level of NO have a positive correlation with the level of ALT.Albumin decreased significantly in severe CHB group,but the level of NO、iNOS was not increase significantly.NO,iNOS and ALT may play an important role in the pathogenesis of CHB,and the levels of NO,iNOS and ALT can be an reference to assess the severity of CHB.

关 键 词：慢性乙型肝炎 一氧化氮 一氧化氮合酶 丙氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学] R916.3[医药卫生—临床医学]