急性颅脑损伤患者凝血-纤溶功能与颅内出血及预后的相关性  

Correlation between Coagulation-Fibrinolysis and Progressive Intracranial Hemorrhage and Prognosis in Patients with Acute Traumatic Brain Injury

作　　者：陈仁辉[1] 崔尧元[2] 盛罗平[1] 陆林其[1] 陈雪林[1] 陈华[1] 顾泉[1] 周浩[2] 

机构地区：[1]复旦大学附属中山医院青浦分院神经外科,上海201700 [2]复旦大学附属中山医院神经外科,上海200032

出　　处：《中国临床医学》2010年第4期487-488,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:研究急性颅脑损伤患者早期凝血-纤溶功能变化与颅内出血和预后的关系。方法:检测196例急性颅脑损伤患者24h内的格拉斯哥昏迷评分(GCS)、凝血酶原时间(PT)、凝血酶时间(TT)、部分活化凝血酶原时间(APTT)、D-二聚体浓度(D-D),作2次或多次CT扫描,分析颅脑损伤患者急性期凝血-纤溶功能的变化与颅内出血和预后的关系。结果:196例颅脑损伤患者的早期D-二聚体浓度变化以颅内血肿患者最为明显,并与颅脑损伤严重程度和预后密切相关。结论:颅脑损伤早期存在凝血-纤溶功能变化,颅脑损伤者早期应密切检查凝血-纤溶功能,如有异常应及时行动态头颅CT检查以及早发现迟发性颅内血肿,提高临床救治水平。Objective：Study the relationship between early change of coagulation-fibrinolysis function and prognosis in acute brain traumatic patients.Methods： The GCS,prothrombin time（PT）,thrombin time（TT）,activated partial thromboplastine time（APTT）,D-dimer（D-D） and CT in 196 acute brain traumatic patients were measured.The relationship between the change of coagutation-fibridysis function and the prevanlence of intracranial hematoma was analyzed.Results： The D-D change was most significant in brain hematoma patients and was closely related to the prognosis.Conclusions： The coagulation-fibrirolysis function changed early in brain traumatic patients and shonld be detected closely.CT scan can detect delayed intracranial hematoma.

关 键 词：颅脑损伤 颅内血肿 预后 

分 类 号：R651.15[医药卫生—外科学]