1-苯并环庚酮的简便合成研究  

Convenient Synthesis of 1-Benzosuberone

作　　者：高磐龙[1] 孙小强[1] 邱太源 

机构地区：[1]江苏工业学院化学化工学院,江苏常州213164 [2]常州元朔化工科技有限公司,江苏常州213164

出　　处：《安徽农业科学》2010年第19期9948-9949,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]考察了1-苯并环庚酮的合成路线。[方法]以1-溴-3-苯基丙烷和丙二酸二乙酯为原料,通过取代反应,制得2-(3-苯丙基)丙二酸,对其加热脱羧得到中间体5-苯基正戊酸,再用多聚磷酸(PPA)环化脱水生成1-苯并环庚酮。[结果]反应总收率达52.9%～61.0%。用IR,1HNMR及MS对中间体、最终产物进行了表征。[结论]该方法操作简便,反应收率高,为1-苯并环庚酮的合成提供了一条经济路线。[Objective] The purpose of this research was to study the synthesis of 1-benzosuberone.[Method] The cyclodehydration of 5-phenylvaleric acid prepared from 1-bromo-3-phenylpropane and diethyl malonate by substitution reaction to give 2-（3-phenylpropyl）-malonic acid which was subjected by decarboxylation with heating,with polyphosphoric acid afforded 1-benzosuberone.[Result] The overall yield was 52.9%-61.0%.Structures of the intermediates and the final product were characterized by IR,NMR and MS.[Conclusion] This method was simple,high efficiency,and provided an economical route for synthesis of 1-benzosuberone.

关 键 词：1-苯并环庚酮 5-苯基正戊酸 合成 

分 类 号：O622.4[理学—有机化学]