高血压合并糖耐量减低患者血浆肿瘤坏死因子α和白细胞介素6水平变化  

Levels of Plasma Tumor Necrosis Factor-α and Interleukin-6 in Hypertensive Patients with Impaired Glucose Tolerance

作　　者：单红英[1] 李海涛[2] 姜晓冬 培文杰[4] 

机构地区：[1]秦皇岛市第三医院心内科,硕士研究生河北秦皇岛066100 [2]华北煤炭医学院附属医院心内科,河北唐山063000 [3]抚宁县医院心内科,河北秦皇岛066300 [4]秦皇岛市第三医院放射科,河北秦皇岛066100

出　　处：《中华高血压杂志》2010年第8期765-768,共4页Chinese Journal of Hypertension

摘　　要：目的观察原发性高血压(EH)合并糖耐量减低(IGT)患者血浆肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化,探讨其与EH合并IGT的关系。方法入选EH患者82例,其中合并IGT者42例,糖耐量正常(NGT)者40例;非EH者80例,其中IGT者40例,NGT者40例。采用ELISA法测定血浆中TNF-α、IL-6含量。结果 EH组TNF-α和IL-6水平高于非EH组[TNF-α(29.61±5.35)比(25.82±4.15)ng/L,IL-6(103.79±21.57)比(83.27±16.27)ng/L,均P<0.05]。所有研究对象中,IGT人群血浆TNF-α、IL-6水平均高于NGT人群。多因素logistic回归分析表明,影响EH合并IGT的因素为TNF-α、IL-6、空腹血糖、餐后2h血糖、体质量指数和收缩压(β分别为0.255、0.061、0.740、1.247、0.247、0.140;均P<0.01)。结论 EH、IGT患者TNF-α和IL-6水平增高。EH合并IGT患者TNF-α和IL-6水平进一步增强。Objective To study the the levels of tumor necrosis factor-alpha（TNFα） and interleukin-6 （IL-6） in patients with essential hypertension（EH） and impaired glucose tolerance （IGT）.Methods We recruited 82 EH patients,40 with normal glucose tolerance（NGT） and 42 with IGT,and 80 normotensives （40 with NGT and 40 with IGT）.The levels of plasma TNFα and IL-6 were determined by enzyme linked immunosorbent assay （ELISA）.Results The levels ofTNF-α and IL-6 in EH group were higher than those in normotensive group [TNF-α（29.61±5.35） vs （25.82±4.15）ng/L,IL-6 （103.79±21.57） vs（83.27 ±16.27）ng/L,all P0.05].Among the participants,the average levels of TNF-α and IL-6 in IGT patients were higher than those in NGT subjects.Multivariate analysis showed TNF-α,IL-6,fasting plasma glucose （FPG）,2 h plasma glucose （2hPG）,body mass index （BMI） and systolic blood pressure were predisposing risk factors for hypertensive patients with IGT （β=0.255,0.061,0.740,1.247,0.247,0.140 respectively,all P0.01）.Conclusion TNF-α and IL-6 are enhanced in hypertensive patients with IGT.

关 键 词：肿瘤坏死因子Α 白细胞介素6 高血压 糖耐量减低 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]