牙龈卟啉单胞菌对心血管内皮细胞黏附和入侵的研究  

Invasion of porphyromonas gingivalis to human coronary artery endothelial cells

作　　者：宋红[1] 马秦[1] 吕昕[1] 赵蕊妮[1] 

机构地区：[1]第四军医大学口腔医学院综合急诊科,陕西西安710032

出　　处：《心脏杂志》2010年第5期692-694,共3页Chinese Heart Journal

摘　　要：目的:牙龈卟啉单胞菌(Porphyromonas gingivalis,P.g)作为牙周炎致病菌,同时也能引起心血管系统的疾病。在本研究中,比较4种P.g对人牙龈上皮细胞,人心血管内皮细胞,和人脐静脉内皮细胞的黏附和入侵。探讨P.g对人牙龈上皮细胞和心血管内皮细胞的黏附和入侵能力。方法:通过抗菌素保护实验检测细菌对各种细胞的黏附和入侵能力。结果:各种细菌的黏附和入侵能力是不同的,相同细菌对不同细胞的黏附和入侵也各有不同,P.g对人牙龈上皮细胞,人心血管内皮细胞的黏附和入侵明显高于对人脐静脉内皮细胞的黏附和入侵。结论:P.g菌株对牙龈上皮细胞和人心血管内皮细胞有着相似的黏附和入侵能力。AIM： To explore the invasion of porphyromonas gingivalis （P. g）, a periodontal pathogen, in the pathogenesis of coronary heart disease. METHODS ： Four different strains of P. g were tested for adhesion and invasion of human gingival epithelial cells （HGEC）, human umbilical vein endothelial cells （HUVEC） and human coronary artery endothelial cells （HCAEC）. The strains were tested for the ability to attach to and invade HGEC, HUVEC and HCAEC using a standard antibiotic protection assay. RESULTS： Data indicated that the invasion efficiency of P. g was different among the different strains. The same strain showed a different ability to adhere to and invade different types of cells. The efficiency of P. g adhesion and invasion of HGEC and HCAEC was higher than HUVEC. CONCLUSION ： P. g strains have a stronger ability to adhere tO and invade both HGEC and HCAEC.

关 键 词：牙龈卟啉单胞菌 牙周炎 心血管疾病 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]