冠状动脉慢血流现象与血清脂质过氧化水平的关系  

Serum lipid peroxidation levels in patients with coronary slow flow

作　　者：拓步雄[1] 李慧[1] 李超民[1] 彭利静[1] 钟筱兰[1] 

机构地区：[1]解放军第四五一医院心血管内科,陕西西安710054

出　　处：《心脏杂志》2010年第5期730-732,共3页Chinese Heart Journal

摘　　要：目的:观察冠状动脉慢血流现象(CSF)患者血清脂质过氧化水平的变化,并探讨CSF的影响因素。方法:采用TIM I帧计数(TFC)法作为测定CSF的指标,将入选病例分为两组:CSF组35例,正常对照组35例,均排除既往冠心病、心肌病及其他类型心脏病。采用生化法测定血清中超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-PX),丙二醛(MDA),过氧化脂质(LPO)的含量。结果:CSF组的血清MDA、LPO明显高于对照组[MDA:(18.9±2.0)μmol/Lv.s(10.5±1.3)μmol/L,P<0.01],[LPO:(2.8±0.4)μmol/Lvs.(1.9±0.2)μmol/L,P<0.01];CSF组血清GSH-PX明显高于对照组[GSH-PX:(0.22±0.04)μmol/Lvs.(0.20±0.03)μmol/L,P<0.05]。CSF组血清SOD明显低于对照组[SOD:(72±11)kU/Lv.s(79±10)kU/L,P<0.01]。在校正体质量指数、总胆固醇、尿素氮等后CSH-PX、MDA、LPO是CSF的危险因素(分别OR=3.987、4.782、3.381;分别为P<0.05、P<0.01、P<0.01)。SOD则是其保护因素(OR=0.892,P<0.05)。结论:CSF患者血清SOD下降,MDA、LPO、GSH-PX上升,体内氧化应激增强。AIM： To observe the levels of serum lipid peroxidation in patients with coronary slow flow （CSF） and to study related factors. METHODS： Thirty-five patients with documented CSF defined according to TIMI frame count method （TFC） and 35 patients with normal coronary flow were enrolled. Levels of superoxide dismutase （ SOD）, glutathione peroxidase （ GSH-PX）, malonyldialdehyde （MDA） and lipid peroxidation （LPO） were determined by biochemistry and logistic regression analysis was per- formed. RESULTS： Baseline data showed that compared with control group, MDA and LPO significantly increased inCSFgroup [MDA： （18.9 ±2.0） vs. （10.5±1.3） mol/L, P〈0. 01], [LPO： （2.8±0. 4） vs. （ 1.9 ±0. 2 ） tool/L, P 〈 0. 01 ]. Serum GSH-PX also increased in CSF group [ GSH-PX ： （0. 22 ±0. 04） vs. （0. 20 ± 0. 03 ） tool/L, P 〈 0. 05 ], but SOD significantly decreased in CSF group [ SOD： （72 ± 11 ） vs. （79 ± 10） kU/L, P 〈 0. 01 ]. After calibration of body mass index, total cholesterol and blood urea nitrogen, analysis showed that CSF was positively correlated with GSH-PX, MDA and LPO （ [3 = 1. 768, 1. 565 and 1. 204, respectively, P 〈0. 05, P 〈0. 01, P 〈0. 01 ） but was negatively correlated with SOD （J3 =0. 115, P 〈0.05）. CONCLUSION： In CSF patients, serum SOD decreases, whereas MDA, LPO and GSH-PX increase. The increased peroxide products of MDA, LPO and GSH-PX enhance oxidative stress in the body, which may result in CSF.

关 键 词：冠状动脉慢血流 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：Q544[生物学—生物化学]