益气活血、化痰解毒中药配合常规治疗防治糖尿病下肢血管病变PTA术后再狭窄  

Effect of Chinese Drugs for Benefiting-qi,Activating-blood,Dissolving-phlegm and Removing-toxin Combined with Conventional Treatment in Preventing and Treating Post-operative Vascular Restenosis in Patients with Diabetic Lower Extremity Arterial Disease Un

作　　者：鞠上[1] 杨博华[1] 崔云龙[1] 曾绩娟[1] 金潇[1] 王宁[1] 周笑允[1] 李友山[1] 王刚[1] 

机构地区：[1]北京中医药大学东直门医院周围血管科,北京100700

出　　处：《中国中西医结合杂志》2010年第9期901-904,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京中医药大学科研基金项目

摘　　要：目的观察益气活血、化痰解毒中药配合常规治疗防治糖尿病下肢血管病变(diabetic lowerextremityarterial disease,DLEAD)患者经皮腔内血管成形术(PTA)术后再狭窄的临床疗效。方法将56例行膝下动脉PTA治疗的DLEAD患者分为中药组(32例)和对照组(24例)。两组均采用基础用药治疗,中药组加用益气活血、化痰解毒中药。观察患者症状体征、患肢踝/肱指数(ankle/brachial index,ABI)、经皮氧分压(transcutaneous oxygen pressure,TCPO_2)的变化,彩色超声检查受治血管。结果两组症状评分、ABI、TCPO_2和彩色超声流速检查结果均优于术前(P<0.05),术后3～6个月对照组上述指标开始下降,中药治疗组疗效稳定,术后6个月中药组有效率为75.00%,ABI为0.65±0.12,TCPO_2为(68.00±4.21)mm Hg,彩色超声流速(35.00±2.11)cm/s;对照组分别为41.67%、0.44±0.12、(41.00±2.02)mm Hg、(21.00±1.85)cm/s,中药组优于对照组(P<0.05)。结论益气活血、化痰解毒中药对DLEAD患者PTA术后再狭窄有一定临床防治作用。Objective To verify the clinical efficacy of Chinese drugs for benefiting-qi,activating-blood, dissolving phlegm and removing-toxin（CDs） Combined with Conventional Treatment on post-operative vascular restenosis in patients with diabetic lower extremity arterial disease（DLEAD） underwent percutaneous transluminal angioplasty（PTA）.Methods Fifty-six DLEAD patients underwent PTA of below-knee artery were assigned to the treatment group（32 patients） treated by basic therapy combined with CDs and the control group（24 patients） treated by basic therapy only.The changes in symptoms and signs,ankle/brachial index（ABI） and transcutaneous oxygen pressure（TCPO_2） of affected limb,and blood flow（BF） in operated vessels checked with color Doppler examination were monitored and analyzed with SPSS software 16.0.Results Overall effectiveness, including symptom score,ABI,TCPO_2 and BF in patients after operation were all better in both groups significantly（P0.05）,the improvements began to reveal in 3-6 months,and be stabilized in the treatment group,but declined gradually in the control group after then.So,the effective rate in the treatment group became significantly higher than that in the control group（75.00%vs.41.67%,P0.01） at the end of the 6th month, meanwhile levels of ABI（0.65±0.12）,TCPO_2（68.00±4.21 mm Hg）,and BF（35.00±2.11 cm/s） in the former were better than those in the control group,respectively（0.44±0.12,41.00±2.02 mm Hg and 21.00±1.85 cm/s,P0.05）.Conclusion CDs shows definite effect in post-PTA prevention of vascular restenosis in DLEAD patients.

关 键 词：糖尿病下肢血管病变 经皮腔内血管成形术 再狭窄 益气活血、化痰解毒 

分 类 号：R259[医药卫生—中西医结合]