清开灵注射液治疗小儿RSV肺炎痰热闭肺证主症不同时点的疗效  

Effect of Qingkailing Injection on Children with Respiratory Syncytial Virus Pneumonia of Phlegm-heat Obstructing Fei Syndrome Pattern at Different Time-points

作　　者：杨燕[1] 汪受传[2] 李瑞丽[2] 白文静[3] 

机构地区：[1]首都医科大学附属北京儿童医院,北京100045 [2]南京中医药大学第一临床医学院 [3]中国中医科学院临床评价中心

出　　处：《中国中西医结合杂志》2010年第9期908-911,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家"十五"科技攻关计划项目(No.2004BA716B03)

摘　　要：目的从主症不同时点的疗效变化评价清开灵注射液治疗小儿RSV肺炎痰热闭肺证的临床疗效。方法对206例患儿进行中西药对照观察,试验组给予清开灵注射液静脉滴注,儿童清肺口服液口服;对照组给予利巴韦林注射液静脉滴注,复方愈创木酚磺酸钾口服液口服,疗程均为10天。对治疗过程中主症(发热、咳嗽、痰壅、气促)不同时点的疗效分别进行评价。结果试验组各主症的优势均表现在早期起效上,起效时间均为第4天,且咳嗽、痰壅症状的优势疗效贯穿于整个疗程。结论中医药在治疗小儿RSV肺炎痰热闭肺证中显示出多靶点的治疗效应。Objective To evaluate the curative effect of Qingkailing Injection（QKL） for treatment of children＇s respiratory syncytial virus pneumonia of phlegm-heat obstructing Fei syndrome pattern（SVP-PH） depending upon main symptom assessment.Methods A Chinese-Western medicine comparative trial was conducted on 206 children with SVP-PH in two groups treated with Ribavilin injection plus compound guaiacol potassium sulfonale oral solution（as control group） and QKL injection plus Ertong Qingfei oral liquid（as treated group） respectively, for 10 days.The curative effectiveness on four main symptoms（fever,cough,sputum and short breath） were evaluated at different time-points.Results The effectiveness in the treated group at various time-points was superior to that in the control group,showing the earlier initiating time（on the 4th day） and the preponderances on cough and sputum ran all through the whole course.Conclusion Chinese medicine shows a multi-target effect in treating children＇s SVP-HP.

关 键 词：清开灵注射液 小儿RSV肺炎 痰热闭肺证 主症 不同时点 疗效评价 

分 类 号：R272[医药卫生—中医儿科学]