新型钯配合物[Pd(Phen)(TsserNO)]·H2O的合成、晶体结构和体外抗肿瘤活性(英文)  

Synthesis, Crystal Structure and Cytotoxicity of a Novel Palladium(Ⅱ) Complex [Pd(Phen)(TsserNO)]·H_2O

作　　者：张金超[1] 李路伟[1] 王立伟[1] 张芳芳[1] 秦新英[1] 李小六[1] 

机构地区：[1]河北大学化学与环境科学学院,河北省化学生物学重点实验室,保定071002

出　　处：《无机化学学报》2010年第9期1699-1702,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家“重大新药创制”科技重大专项(No2009ZX09103-139);973计划前期研究专项(No2010CB534913);科技部“科技人员服务企业行动项目”(No2009GJA20025);河北省应用基础研究计划重点基础研究项目(No08966415D);河北省教育厅科学研究计划课题(No2008311)资助

摘　　要：A novel palladium(Ⅱ) complex [Pd(Phen)(TsserNO)]·H2O (Phen=1,10-phenanthroline; TsserNO=4- toluenesulfonyl-L-serinate dianion) has been prepared and structurally characterized, the cytotoxicity in vitro has also been investigated by MTT and SRB assays. The complex crystallizes in the monoclinic system, space group P21 with cell parameters a=0.618 64(14) nm, b=1.768 9(4) nm, c=0.990 2(2) nm, β=102.392(4)°, V=1.058 3(4) nm3 and Z=2. The complex had selectivity against HL-60, BGC-823, Bel-7402 and KB cells lines, its cytotoxicity is equal to that of cisplatin against BGC-823 and Bel-7402 cells lines, however it is less potent than cisplatin against HL-60 and KB cell lines.<Keywords>antitumor; palladium(Ⅱ) complex; crystalA novel palladium（Ⅱ） complex [Pd（Phen）（TsserNO）]·H2O （Phen=1,10-phenanthroline; TsserNO=4- toluenesulfonyl-L-serinate dianion） has been prepared and structurally characterized, the cytotoxicity in vitro has also been investigated by MTT and SRB assays. The complex crystallizes in the monoclinic system, space group P21 with cell parameters a=0.618 64（14） nm, b=1.768 9（4） nm, c=0.990 2（2） nm, β=102.392（4）°, V=1.058 3（4） nm3 and Z=2. The complex had selectivity against HL-60, BGC-823, Bel-7402 and KB cells lines, its cytotoxicity is equal to that of cisplatin against BGC-823 and Bel-7402 cells lines, however it is less potent than cisplatin against HL-60 and KB cell lines.

关 键 词：抗肿瘤 钯髤配合物 单晶结构 

分 类 号：O614.823[理学—无机化学]