大鼠颈椎病实验模型的设计与建立  

The Design and Establishment of a Model of Experimental Cervical Spondylosis in the Rat

作　　者：郝永强[1,2,3,4] 施杞[1,2,3,4] 郑松国 谢可永[1,2,3,4] 朱振东 沈培芝 

机构地区：[1]上海中医药大学附属龙华医院骨科 [2]上海第二医科大学附属第九人民医院骨科 [3]上海中医药大学骨伤研究所 [4]上海医科大学附属肿瘤医院病理科

出　　处：《中国矫形外科杂志》1999年第4期282-283,共2页Orthopedic Journal of China

摘　　要：目的：建立一种理想的颈椎病实验模型。方法：３０只大鼠随机分为实验模型组与对照组，每组１５只。实验模型组借助手术方法直接切除大鼠颈背部伸肌群，对照组行伪手术。造模术后２月、４月、６月选择实验模型组、对照组大鼠各５只，取其颈椎（Ｃ３～７）作组织形态学观察，并相互比较。结果：实验模型组大鼠颈椎间盘退变较对照组明显加快、加重，出现与人类颈椎病相类似的病理改变。结论：颈部肌肉软组织即动力平衡因素在颈椎病发病机理中意义重大。Objective:To establish an ideax model of the experimental cervical spondylosis.Method:Thirty Sprague Dawley rats were elected and randomly divided into two groups (15 rats for the experimental group and 15 rats for the control group).The cervical dorsal extensors of each rat in the experimental group were excised.Five rats from each group were killed 2,4,6 months after operation.Pathologic histology of the cervical vertebrae was observed in a light microscope after staining with hematoxylin and eosin.Results:The results revealed that cervical vertebrae of rat in the experimental group degenerated more fast and seriously than that in the control group.The pathological changes were similar to those of the cervical spondylosis in the human being.Conclusion:On the dasis of this study,it is concluded that cervical muscles as well as other soft tissue (cervical dynamic eqilibrium)have a great significance in courxe of pathogenesis of cervical spondylosis.

关 键 词：大鼠 颈椎病 模型 动力性平衡 

分 类 号：R681.55[医药卫生—骨科学]