64层CT灌注成像评价周围动脉闭塞性疾病的临床应用研究  

Application of 64-Slice CT Perfusion in Peripheral Arterial Occlusive Diseases

作　　者：卢再鸣[1] 孔繁星[1] 陆晓梅[1] 任国强[1] 郭文力[1] 郭启勇[1] 

机构地区：[1]中国医科大学附属盛京医院放射科,辽宁沈阳110004

出　　处：《中国医学影像学杂志》2010年第5期426-429,共4页Chinese Journal of Medical Imaging

基　　金：辽宁省教育厅创新团队项目(2007T182)

摘　　要：目的:探讨CT灌注成像在评价周围动脉闭塞性疾病方面的应用价值。材料和方法:采用64排螺旋CT对24例周围动脉闭塞性疾病患者和14例正常志愿者进行下肢CT灌注扫描,计算血容量(blood volume,BV)、血流量(blood flow,BF)、平均通过时间(mean transit ti me,MTT)和灌注达峰时间(ti me to peak,TTP)灌注参数,分析缺血组与对照组各灌注参数之间的差异。将周围动脉闭塞性疾病患者根据病情严重程度的Fontaine分级分成4组,分别对比4个组之间各灌注参数的差异。结果:缺血组BV、BF参数患病下肢均低于对照组(P<0.05)。缺血组临床分级各组之间BV值均存在显著差异(P<0.05),BF在Ⅰ级和Ⅲ级间差异有统计学意义(P<0.05)。MTT和TTP在各级别组间差异均无统计学意义(P>0.05)。结论:BV、BF值可作为CT灌注成像评价周围动脉闭塞性疾病病情轻重的参考指标。Purpose To evaluate the clinical application of CT perfusion in peripheral arterial occlusive disease（PAOD）.Materials and Methods Twenty-four patients with PAOD and 14 healthy volunteers underwent CT perfusion of lower extremities.The perfusion indexes of blood volume（BV）,blood flow（BF）,mean transit time（MTT）and time to peak（TTP）were obtained and compared between the patients and the controls.The patients were graded by Fontaine grade and compared between each two groups.Results The index of BV and BF were significantly higher in patients than in PAOD（P〈0.05）.BV showed statistical difference between each two of the Fontaine grades（P〈0.05）.BF had statistical difference between grade I and grade Ⅲ（P〈0.05）.MTT and TTP had no difference between each two groups（P〈0.05）.Conclusion The BV and BF of CT perfusion is useful in evaluating the severity of PAOD.

关 键 词：CT灌注成像 动脉闭塞性疾病 体层摄影术 螺旋计算机 

分 类 号：R543.504.54[医药卫生—心血管疾病]