醋炔诺酮丙酰肟对鼠的抗生育作用研究  

THE ANTI-FERTILITY ACTIVITY OF NORETHISTERONE ACETATE-3-PROPIONYLOXYIMINO

作　　者：陶倩萍 金爱华[1] 张寅恭[1] 朱家蕙[1] 焦捷军 邵庆翔[1] 

机构地区：[1]浙江医学科学院计划生育研究所

出　　处：《生殖与避孕》1990年第4期41-46,共6页Reproduction and Contraception

摘　　要：醋炔诺酮丙酰肟在大鼠和小鼠妊娠1～5天口服的抗着床ED_(50)分别为0.068±0.02和0.31±0.1mg/kg,大鼠妊娠第2天单次肌注或口服的抗着床ED_(50)分别为0.53±0.1和3.5±0.7mg/kg。大鼠妊娠7～8天肌注5～10mg/kg醋炔诺酮丙酰肟有明显的终止早孕作用。醋炔诺酮丙酰肟在终止早孕剂量时,明显抑制假孕大鼠的蜕膜反应且使早孕大鼠的血清孕酮浓度明显下降。提示:醋炔诺酮丙酰肟的终止早孕作用可能与其抑制孕激素活性有关。Norethisterone acetate-3-proplonyloxyimino (NAP) was significantly effective for anti-implantation and early pregnancy termination in both gravid rats and mice. The anti- implantation ED_(50) by gavage from day 1-5 of gravidity in rats and mice were 0.068±0.02 and 0.31 ± 0.1 mg/kg respectively, and 0.53 ± 0.1 and 3.5 ± 0.7 mg/kg respectively in rats by intramuscular injection and gavage on day 2 of gravidity. The early pregnancy termination doses in rats were 5 and 10 mg/kg by intramuscular injection on day 7～8 of gravidity. A dose of NAP sufficient to terminate the early pregnancy obviously inhibited the decidua reaction in pseudopregnant rats and reduced the serum progesterone concentration of early pregnant rats quite markedly. The early pregnancy termination action of NAP might be related to its anti-progesterone activity.

关 键 词：醋炔诺酮肟 炔诺酮肟 抗早孕 

分 类 号：R979.21[医药卫生—药品]