交联海藻酸钠微囊的制备及其在药物缓释中的应用  

Preparation of Cross-linked Sodium Alginate Microcapsules and Application in Releasing Drag

作　　者：高健[1] 

机构地区：[1]连云港职业技术学院医药与化学工程学院,江苏连云港222006

出　　处：《连云港师范高等专科学校学报》2010年第2期93-95,共3页Journal of Lianyungang Normal College

基　　金：2009年度连云港市科技攻关项目(项目编号:CG0915)

摘　　要：以海藻酸钠与戊二醛的交联反应制备交联海藻酸钙微囊,通过交联时间可以控制微囊的交联程度。用扫描电子显微镜测定微囊粒径大小及其形态,用高效液相色谱测定微囊中卡托普利的释放速度。结果表明:微囊粒径分布在180-230μm之间,粒径分布范围较窄,在乙醇溶液中对卡托普利具有缓释作用。Polymeric sodium alginate microparticles were prepared by cross-linking sodium alginate with glutaraldehyde.The extent of cross-linking was controlled by the time of exposure to glutaraldehyde.The sizes of the microcapsules with a diameter of 180-230μm were detected by Scanning Electron Microscopy（SEM）.The release ratio of the Captopril from the microcapsules into an ethanol solution was monitored by High Performance Liquid Chromatography（HPLC）.Experiment showed that the Captopril from the microcapsules released slowly in ethanol solution in 24 hour.

关 键 词：海藻酸钠 交联 戊二醛 微囊 

分 类 号：TQ460.4[化学工程—制药化工]