中性粒细胞缺乏期感染的综合防治  

Comprehensive Prevention and Treatment for Infection in the Periods of Granulocytopenia

作　　者：卢进[1] 尹序德[1] 李维[1] 卫述群[1] 曾令源[1] 郑智元[1] 

机构地区：[1]四川省肿瘤医院

出　　处：《临床血液学杂志》1999年第3期111-113,共3页Journal of Clinical Hematology

摘　　要：目的：探讨接受联合化疗的恶性肿瘤患者在中性粒细胞缺乏期感染的发生情况及相关因素。方法：１０４ 例接受联合化疗患者在中性粒细胞缺乏期分别采用综合措施，即层流室隔离，预防性应用抗生素、ＧＭ－ＣＳＦ激活骨髓等，单用抗生素防治，两组病例均为５２ 例。结果：综合组中性粒细胞恢复快，粒细胞缺乏期明显缩短，仍有８ 例发生感染，感染率１５．４％ ，但程度轻，预后好，无霉菌感染；单用抗生素组１４ 例发生感染，感染率２６．９％ ， Ｐ＞ ０．０５，差异无显著性，２ 例合并霉菌感染，死亡２例。结论：综合措施防治联合化疗中性粒细胞缺乏期感染是有效的。Objective:To investigate the infective rates and relative factors in the peroids of granulocytopenia in maglinancies with combined chemotherapy.Methods:104 patients with granulocytopenia after combined chemotherapy were treated with comprehensive treatment isolation in lamin air flow room, injection of antibiotics and GM CSF and injection of antibiotics only.Results:Granulocyte recovered rapidly and the periods of granulocytopenia were markedly shortened in comprehensive group. 8 cases were infected, infective rate was 15.4 %, all of which had ligh degrees and good prognoses. No fungus infection was happened. 14 cases were infected in antibictic treatment group and infective rate was 26.9 %. Both had no significant difference (P> 0.05 ) 2 Cases were infected by fungus and 2 cases were caused to death.Conclusion:The effects of comprehensive treatment for infection in patients with granulocytopenia were satisfied.

关 键 词：联合化疗 中性粒细胞缺乏 感染 防治 

分 类 号：R557.3[医药卫生—血液循环系统疾病]