不同方法治疗他巴唑致粒细胞缺乏症的疗效比较  

Comparison of the Efficacy in Treating Methimazole-induced Agranulocytosis with Different Methods

作　　者：徐毅[1] 

机构地区：[1]贵州省贵阳医学院附属医院内分泌科,550004

出　　处：《中华全科医学》2010年第11期1379-1380,共2页Chinese Journal of General Practice

摘　　要：目的对比不同方法治疗他巴唑致粒细胞缺乏症的疗效,以指导临床治疗。方法 15例他巴唑(MMI)致粒细胞缺乏症患者,所有病例均停用他巴唑。病例随机分为3组,采用不同的治疗方案,A组:5例,采用普通治疗;B组:5例,采用普通治疗加用糖皮质激素(强的松30mg/d);C组:5例,在普通治疗基础上加用重组人粒细胞集落刺激因子(rhG-CSF),300μg/d皮下注射。以上各组每日复查血常规,观察中性粒细胞恢复到>2.0×109/L的时间。结果 A、B、C组中性粒细胞数恢复正常时间分别为(12.8±0.4)d、(12.6±0.5)d、(6.4±0.5)d,B组与A组比较差异无统计学意义。C组与A、B组比较差异有统计学意义(P<0.001)。结论糖皮质激素在MMI导致粒细胞缺乏症治疗中可能是无效的;rhG-CSF在MMI致粒细胞缺乏症治疗中是最有效的。Objective To compare the effect of different treatment methods of methimazole-induced agranulocytosis,and to guide clinical treatment.Methods 15 cases of methimazole-induced agranulocytosis patients were out of methimazole.They were randomly divided into three groups with different treatment options,A group：5 cases,the ordinary treatment;B group：5 cases with conventional therapy plus corticosteroids（prednisone 30 mg/d）;C group：5 cases,the general treatment plus employing recombinant human granulocyte colony stimulating factor（rhG-CSF）,300 μg/d subcutaneously.Examin Blood routine everyday,to observe neutrophil recovery to 2.0×10~9/L of the time.Results A,B,C group neutrophil recovery time was（12.8±0.4）d,（12.6±0.5）d,（6.4±0.5）d,B Group and A Group with no significant difference in statistics.C group and A,B group in difference was significant in statistics（P0.001）.Conclusion Glucocorticoids in methimazole-induced agranulocytosis treatment may be ineffective;The method of using rhG-CSF to treat methimazole-induced agranulocytosis is the most effective.

关 键 词：他巴唑 粒细胞缺乏症 人重组粒细胞集落刺激因子 

分 类 号：R977.15[医药卫生—药品] R994.11[医药卫生—药学]