SLE患者血清DNA水平测定的临床意义  

The Measurement of Serum DNA and Its Clinical Significance in Patients with SLE.

作　　者：曾凡钦[1] 陈宜芳[1] 李伯有[1] 陈伟雄[1] 许德清[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院皮肤科

出　　处：《中国皮肤性病学杂志》1999年第3期137-139,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的检测ＳＬＥ患者血清ＤＮＡ含量并探讨其在ＳＬＥ发病中的作用。方法用荧光分光光度法测定了６３例ＳＬＥ患者。结果ＳＬＥ患者血清ＤＮＡ含量明显高于正常人；活动期患者明显高于缓解期患者，但是伴肾功能损害的患者其血清ＤＮＡ水平普遍较低。血清ＤＮＡ水平与血沉、ＡＮＡ呈正相关；与Ｃ３、Ｃ４呈负相关；与抗ｄｓＤＮＡ抗体无相关；与病情积分呈正相关。结论ＳＬＥ患者存在ＤＮＡ的代谢异常，血中ＤＮＡ在ＳＬＥ的发生发展中起着一定作用，血清ＤＮＡ含量的测定可做为判断疾病活动的敏感指标。Objective To measure the content of serum DNA in SLE patients and study the contribution of the abnormality of serum DNA in the development of SLE.Method 63 serum samples of SLE patients were measured by fluorescence spectrophotometer method.Results The content of serum DNA in patients was higher than that in mormal individuals,in patients of active stage was significantly higher than that of resolving stage.The patients with lupus nephritis had a lower serum DNA level compared with non nephritis patients.The serum DNA was positive correlated with ANA,ESR;negative correlated with C 3,C 4. There was no correlation between DNA and anti DNA antibody.In addition,serum DNA concentration was closely positive correlated with the grade of activity of disease.Conclution There was abnormal metabolism of DNA in SLE patients.The DNA in blood circulation plays a important role in the development and progeression of SLE.The serum DNA content can reflect SLE activity more sensitively.

关 键 词：系统性红斑狼疮 DNA 测定 血清 

分 类 号：R593.241[医药卫生—内科学]