异丙酚对内毒素血症兔肠道的作用  

Effects of propofol on intestine of rabbits with endotoxemia

作　　者：梅勇[1] 徐鑫荣[1] 

机构地区：[1]江苏省人民医院,210029

出　　处：《中国医学创新》2010年第23期23-24,共2页Medical Innovation of China

摘　　要：目的探讨异丙酚对内毒素血症兔肠道的作用。方法连续静脉内注射内毒素复制内毒素血症模型。新西兰大白兔40只,随机分为5组,每组8只。A组为空白对照组;B、C、D、E组均给予内毒素(600μg/kg)。C、D、E组均为内毒素注入后30 min后予以异丙酚持续静脉泵入[C组5 mg/(kg·h)、D组10 mg/(kg·h)、E组15 mg/(kg·h)]。4 h后测定血浆二胺氧化酶(DAO)的活性。测定小肠髓过氧化物酶(MPO)活性、超氧化物歧化酶(SOD)活性、脂质过氧化产物丙二醛(MDA)的含量。结果与B组相比C、D、E组均能不同程度的降低DAO的活性、小肠MPO活性,增加小肠SOD活性,降低小肠MDA含量(P<0.05)。结论异丙酚对内毒素血症兔肠道具有保护作用,并非异丙酚剂量越大效果越好。Objective To study the effects of propofol in different doses on intestine in rabbits with endotoxemia.Methods Endotoxemia was replicated by continuous infusion of E- coli lipopolysaccharides(LPS) in rabbits.Forty New Zealand rabbits were randomly divided into 5 groups:A,nonnal controls(n = 8);B,LPS group(n = 8),receiving intravenous endotoxin(LPS 600μg/kg);C,low-dose group(n =8);D,medium- dose group(n = 8);E,high- dose group[n = 8,receiving propofol 5 mg/(kg · h),10 mg/(kg · h) and 15 mg/(kg · h) respectively and LPS 600 μg/kg].The specimens were collected 4 hours later.We observed the following changes:plasma diamine oxidase(DAO)activity,intestine tissue myeloperoxidase(MPO) activity,intestine tissue superoxide dismutase(SOD) activity,intestine tissue malonaldehyde(MDA)content.Results DAO,MPO and MDA content in group C,D and E decreased significantly compared with those of group B(P <0.05).SOD activity in group C,D and E increased markedly compared with group B(P <0.05).Conclusion Propofol has a protective effect on intestine in rabbits with endotoxemia,which is not positively correlated with the dosage.

关 键 词：内毒素血症 肠道 异丙酚 

分 类 号：R614[医药卫生—麻醉学]