单核巨噬细胞集落刺激因子对创面愈合及血管新生调控的研究进展  

Progress in the Studies of Granulocyte/Macrophage Colony-Stimulating Factor Regulating the Angiogenesis and Wound Healing

作　　者：李晓光[1] 方勇[1] 姚敏[1] 

机构地区：[1]上海交通大学医学院第三人民医院烧伤整形科,上海201900

出　　处：《医学综述》2010年第18期2721-2724,共4页Medical Recapitulate

基　　金：国家自然科学基金(30872682)

摘　　要：单核巨噬细胞集落刺激因子是一种具有多效能的生长因子,具有促进创面愈合的重要作用。单核巨噬细胞集落刺激因子在创面愈合过程中的每个阶段都发挥着重要的作用,主要表现为:趋化并激活炎性细胞,提高创面抗感染能力;促进创面角质细胞、成纤维细胞、血管内皮细胞的增殖和分化;有助于创面愈合的细胞因子的分泌。近年来,单核巨噬细胞集落刺激因子对创面愈合及血管新生调控的研究成为热点,现予以综述。Granulocyte/macrophage colony-stimulating factor is a multifunctional growth factor,which has an important role in promoting wound healing.Previous studies showed that granulocyte/macrophage colony-stimulating factor played an important role in every stage of wound healing,including chemotaxis and activation of inflammatory cells,enhancement of wound resistance to infection,promotion of keratinocytes,fibroblasts,vascular endothelial cell proliferation and differentiation,contribution to cytokine secretion.In recent years,granulocyte/macrophage colony-stimulating factor in regulating wound healing and angiogenesis has become popular and therefore be reviewed in this paper.

关 键 词：单核巨噬细胞集落刺激因子 创面愈合 血管新生 

分 类 号：R654.3[医药卫生—外科学]