细胞生长因子对失神经骨骼肌萎缩的作用机制分析  

The Mechanisms of the Cell Growth Factors on Denervated Muscle Atrophy

作　　者：王光[1] 唐志宏[1] 邹国耀[2] 

机构地区：[1]桂林医学院附属医院骨外科,广西桂林541001 [2]桂林医学院解剖教研室,广西桂林541001

出　　处：《医学综述》2010年第18期2754-2757,共4页Medical Recapitulate

摘　　要：外伤、神经病变等多种疾病可引起神经损伤,骨骼肌失神经支配后不可避免地发生萎缩,而轴突再生需要相当长的时间,在肌肉获得神经再支配前,肌肉已经发生不可逆转的萎缩。研究表明,细胞生长因子可促进细胞再生,抑制骨骼肌萎缩。然而,单个因子对骨骼肌萎缩的抑制效果并不明显。通过对生长因子作用机制的理论分析,提出多种生长因子协同作用失神经骨骼肌萎缩的可能性。对多种生长因子协同作用的研究将促进肌萎缩的临床治疗。Trauma,neurological diseases and other diseases can cause nerve damage.Denervation will unavoidably result in an atrophy of skeletal muscles.Axonal regeneration will take a long time.Thus,irreversible atrophy takes place before muscle obtains reinnervation.The results show that cell growth factor can promote cell regeneration and inhibit skeletal muscle atrophy.However,the single factor′s inhibiting effect is not obviously.This paper theoretically analyzes the mechanism of growth factors,addressing the possibility of multiple growth factors′ synergy on denervated skeletal muscle atrophy.The synergy of multiple growth factors is considered will promote the muscle atrophy in clinical treatment.

关 键 词：细胞生长因子 骨骼肌 失神经肌萎缩 

分 类 号：R685.4[医药卫生—骨科学]