帕金森病早期诊断的研究进展  

Research Advances in Early Diagnosis of Parkinson′s Disease

作　　者：封华[1] 刘承伟[1] 

机构地区：[1]桂林医学院病理解剖学教研室,广西桂林541004

出　　处：《医学综述》2010年第18期2775-2777,共3页Medical Recapitulate

摘　　要：帕金森病是一种常见慢性老年性退行性神经系统疾病。临床上早期帕金森病患者的临床症状隐匿,诊断较难。近年来,代谢组学、蛋白组学以及基因诊断、功能影像学等成功应用于帕金森病的早期诊断中,提高了帕金森病患者的早期诊断率;在功能影像学中,如多巴胺类显像、多巴胺转运蛋白的功能显像、磁共振成像和磁共振波谱等无创性诊断方法更是显示出了强大的应用潜力。Parkinson′s disease（PD）is a common senile chronic neurological disease.Early clinical symptoms of PD are insidious,making the diagnosis substantially difficult.In recent years,its early diagnosis is significantly improved due to the application of metabonomics,proteomics,genetic diagnosis and imaging technology.Particularly,imaging diagnostics,such as dopamine and dopamine transporter protein imaging,magnetic resonance imaging（MRI）,magnetic resonance spectroscopy（MRS）and other non-invasive diagnostic methods,also has strong potential of application.

关 键 词：帕金森病 早期诊断 生物学标志物 代谢组学 蛋白组学 

分 类 号：R446[医药卫生—诊断学] R445[医药卫生—临床医学]