低氘水对小鼠免疫调节作用的研究  

Effect of Deuterium-Depleted Water on Immunomodulation in Mice

作　　者：连璐[1] 丛峰松[2] 蔡东联[1] 曲丹[1] 林宁[1] 王洁[1] 

机构地区：[1]第二军医大学长海医院临床营养科,上海200433 [2]上海交通大学生命科学技术学院,上海200240

出　　处：《氨基酸和生物资源》2010年第3期59-62,共4页Amino Acids & Biotic Resources

摘　　要：探讨低氘水(deuterium-depleted water,DDW)对小鼠免疫调节的作用。实验组小鼠以低氘水作为饮用水,对照组饮自来水,饲养6周,分别测定免疫蛋白IgG,,IgM的含量,脾脏指数和胸腺指数(mg/g),脾淋巴细胞增殖能力,迟发型变态反应,NK细胞活性以及T细胞亚群CD4+和CD4+/CD8+的变化,观察低氘水对小鼠非特异性免疫和特异性免疫功能的影响。结果低氘水能显著提高IgM,脾脏指数的水平和CD4+,CD4+/CD8+的含量。低氘水对小鼠非特异性免疫和特异性免疫功能具有一定的增强作用。To evaluate the immunomodulating effects of deuterium-depleted water（DDW） on normal mice,all of the mice were divided into 2 groups.One was the experimental group accepted DDW as the water,and another was the control group.After 6 weeks,IgG,IgM,thymus index,spleen index,the proliferation of spleen lymphocytes,the activity of NK cell,CD4^＋,CD4^＋/CD8^＋ and dinitrofluorobenzeneinduced delayed type hypersensitivity test（DTH） were employed to evaluate the immunomodulating effects of DDW on non-specific and specific immunologic function of normal mice.DDW increased the level of IgM,spleen index,CD4^＋ and CD4^＋/CD8^＋.DDW improved non-specific and specific immunologic function of normal mice.

关 键 词：低氘水 IGG IGM 迟发型变态反应 NK细胞活性 CD4+ 免疫调节 

分 类 号：R392[医药卫生—免疫学]