2型糖尿病周围神经病变与糖化血红蛋白及C肽的相关性研究  

Investigation of the relationship between HbAlc、C-peptide and diabetic peripheral neuropathy in type 2

作　　者：韦华[1] 王民登[1] 李凤玲[1] 蒙连新[1] 吴标良[1] 刘虹兵[1] 李天资[1] 

机构地区：[1]右江民族医学院附属医院,广西百色533000

出　　处：《右江医学》2010年第5期528-529,共2页Chinese Youjiang Medical Journal

基　　金：2008年百色市科技厅资助项目(编号:百科计字[2008]11号)

摘　　要：目的探讨糖化血红蛋白(HbAlc)、C肽(C-P)、空腹血糖(FBG)、餐后2 h血糖(2 hPBG)在糖尿病周围神经病变(DPN)发生和发展中的临床意义。方法对2008年7月至2010年7月200例2型糖尿病患者及100名健康者进行HbAlc、FBG、2 hPBG、C肽等水平检测,并采用欧米诺膏贴和神经肌电图检查,进行DPN的诊断、分类。研究对象分为正常对照组、糖尿病周围神经病变(DPN)组和非糖尿病周围神经病变(NDPN)组;DPN组进一步分为运动纤维异常、感觉纤维异常、运动+感觉纤维异常3个亚组。结果①DPN组和NDPN组与正常对照组比较,HbAlc、空腹C肽(FC-P)、餐后2 hC肽(2 hC-P)、FBG、2 hPBG指标均有统计学差异(P<0.01);DPN组和NDPN组比较,HbAlc2、hPBG明显升高,FC-P下降且均有统计学意义(P<0.01)。②DPN组内不同纤维异常者和NDPN组比较,同时合并运动+感觉纤维异常者HbAlc明显升高而FC-P、2 hC-P明显下降,且均有统计学意义(P<0.01)。③HbAlc控制组DPN发生率较HbAlc未控制组少,比较有统计学意义(P<0.01)。结论 HbAlc、FC-P与DPN发生、发展相关;HbAlc可能会是早期发现DPN的理想监测指标。Objective To study the relationship between glycosylated hemoglobin （HbAle）,C-peptide, fasting blood glucose（FBG）,2 hour postprandial blood glucose（2 hPBG） and diabetic peripheral neuropathy （DPN）in type 2. Methods 100 normal persons and 200 diabetics patients were chosen during Jul 2007 to Jul 2010. Their HbAlc,C- peptide,FBG,2 hPBG were tested. The Neuropad early detection plaster for diabetic foot neuropathy and the electron-euromyography were used for diagnosis of the DPN. The patients were divided into three groups（normal group, non- DPN and DPN groups） according to peripheral neuropathy. DPN group was divided into three subgroups： sensus nerve abnormality group,sensus-motion abnormal,sensus and motion abnormality group. Results ①HbAlc,2 hPBG in DPN group were significantly increased than those in NDPN group, but FC- P were significantly decreased （ P 〈 0. 0 1 ）. ②HbAlc in sensus and motion abnormality group were significantly increased than those in sensus nerve abnormality group,sensus-motion abnormal,but FC-P,2 hC-P were significantly decreased（ P〈0.01）. ③DPN cases significantly decreased after HbAlc intervention. Conclusion HbAlc,FC-P were correlated with the occurrence and development of diabetic peripneral neuropathy, HbAlc can be an ideal detective stander for the diabetic peripneral neuropathy.

关 键 词：糖尿病 神经病变 C肽 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌]