尼莫地平治疗重度迟发型Vit K缺乏性颅内出血后神经损害的临床研究  

Clinical Study of Nerve Injury of Nimodipine Treatment of Severe Late-onset Vit K Deficiency with Intracranial Hemorrhage

作　　者：惠晓霞[1] 杨红[1] 何长生[1] 秦小菀[1] HUI Xiao-xia,YANG Hong,HE Chang-sheng,QING Xiao-wan （Intensive care unit （PICU） Children＇s Hospital Nanyang city of Henan Province ,Nanyang 473000,China）

机构地区：[1]河南省南阳市中心医院儿童重症监护病区（PICU）,河南南阳473000

出　　处：《医学信息》2010年第19期3560-3561,共2页Journal of Medical Information

摘　　要：目的研究尼莫地平在治疗重度迟发型Vit K缺乏性颅内出血后神经损害的影响。方法回顾性分析2001年06月～2007年10月入住我科的50例重度迟发型Vit K缺乏性颅内出血患儿。将50例患儿随机分为治疗组和对照组,采用双盲试验进行临床病例对照研究。对照组仅给予一般的支持和对症处理;治疗组除一般常规治疗外,加用尼莫地平0.2～0.5ug/kg/min持续泵维,五天后改为尼莫地平1～2mg/kg/d分两次口服。结果对照组25例患儿经一般治疗后,其中8（32%）例患儿其神经损害获得了早期显效,6（24%）例患儿有效,11（44%）例患儿无效;10（40%）例患儿获得远期显效,8（32%）例患儿有效,7（28%）例患儿无效。治疗组25例患儿经尼莫地平治疗后,其中18（72%）例患儿其神经损害获得了早期显效,6（24%）例患儿有效,1（4%）例患儿无效;20（80%）例患儿获得了远期显效,5（20%）例患儿有效。结论尼莫地平能明显降低神经系统的损害。Objective Study of the impact of nimodipine on the nerve damage after the severe late-onset intracranial hemorrhage with vitamin K deficiency.Methods A retrospective analysis in June 2001 ~ October 2007 ,children admitted in our department a Section 50 cases of severe delayed-type vitamin K deficiency in children with intracranial hemorrhage.50 patients were randomly divided into treatment group and control group,double-blind clinical trial conducted case-control study.The control group were given general support and symptomatic treatment;treatment group addition to the normal routine treatment,nimodipine was added 0.2 ~ 0.5ug/kg/min continuous pump-dimensional,five days later changed to nimodipine 1 ~ 2mg/kg / d in two oral.Results The control group,25 cases of children after general treatment,of which 8 （32%） cases of neurological damage in children received their early markedly,6 （24%） cases of children with effective,11 （44%） cases of children with valid ;10 （40%） cases of children with access to long-term markedly,8 （32%） cases of children with effective,7 （28%） cases of children is invalid.Treatment group,25 cases of children after nimodipine treatment,of whom 18 （72%） cases of neurological damage in children received their early markedly,6 （24%） cases of children with effective,1 （4%） cases of children with invalid;20 （80%） cases of children with access to a long-term markedly,5 （20%） cases of children effectively.Conclusion Nimodipine can significantly reduce the damage to the nervous system.

关 键 词：尼莫地平 重度 迟发型Vit K缺乏 颅内出血 神经损害 

分 类 号：R972[医药卫生—药品;医药卫生—药学]