3,5-二甲基苯胺合成方法的改进  

Improving on the Synthesis of 3, 5-Dimethylaniline

作　　者：周瑞明[1] 范斌松[2] 吴中柳 沈永嘉[2] 

机构地区：[1]温州师范学院,温州325003 [2]华东理工大学

出　　处：《染料工业》1999年第2期33-36,共4页Dyestuff Industry

摘　　要：以2，4－二甲基苯胺为起始原料研究了合成3，5－二甲基苯胺的方法，对国外已有的五步反应法，即酰化、硝化、水解、去氨基及还原，进行了改进，将酰化与硝化、水解与去氨基分别合并，使总反应简化为三步。在硝化中降低了醋酸用量，代之以价格便宜的硫酸；在水解中以硫酸代替盐酸，从而大大地缩短了反应时间，给出了反应中间产物及3，5－二甲基苯胺的红外光谱、核磁共振和质谱等光谱数据。3, 5-Dimethylaniline has been synthesized by using 2, 4-dimethylaniline as astarting material. Traditionally, it could be obtained through acylation, nitration, hydrolysis, deamination and reduction. According to the characteristics of these reactions, acylationand nitration, hydrolysis and deamination can be combined respectively so that the syntheticprocedure could be reduced to three steps instead of five.By studying the factors of affectingthe reaction, some improvements have been taken, for example, using sulfuric acid asmedium of the nitration and hydro1ysis, in order to decrease the cost of the reaction and reduce the reaction time. The product and intermediates of the reaction were characterized byIR, MS and 1H-NMR spectra.

关 键 词：二甲基苯胺 合成 方法 颜料 中间体 

分 类 号：TQ246.31[化学工程—有机化工] TQ620.4