黄芩苷对高糖培养条件下内皮细胞粘附分子水平的影响  

Effect of Baicalin on Adhesion Molecules of CRL1730 Cells Exposed to High Glucose

作　　者：曾敬[1] 王静[2] 张蕾[1] 张海燕[1] 唐俊明[2] 王家宁[2] 

机构地区：[1]郧阳医学院附属人民医院中医科,湖北十堰442000 [2]郧阳医学院,湖北十堰442000

出　　处：《四川中医》2010年第9期52-53,共2页Journal of Sichuan of Traditional Chinese Medicine

基　　金：湖北省教育厅基金项目(编号:B200724007)

摘　　要：目的:研究黄芩苷对高糖条件下人脐静脉血管内皮细胞株(CRL1730)细胞粘附分子水平的影响。方法:CRL1730细胞常规培养传代,在不同糖浓度培养基(5.5mmol/L、30mmol/L)、黄芩苷(50mg/L、100mg/L、200mg/L)条件下培养48h。酶联免疫吸附法测sICAM-1、sVCAM-1。结果:黄芩苷能抑制高糖导致的内皮细胞粘附分子增高。结论:黄芩苷对高糖状态下CRL1730细胞sICAM-1、sVCAM-1的增高具有抑制作用,其原因可能与其抑制炎症反应等因素有关。Objectives：To investigate the effect of Baicalin on adhesion molecules in cultured human umbilical vein endothelial cells（CRL 1730）exposed to high glucose.Methods：The cultured CRL1730 exposed to high glucose were treated with Baicalin（50 mg/L,100 mg/L,200 mg/L）for 48 hours.Adhesion molecules of CRL 1730 were by ELESA.Results：Baicalin groups adhesion molecules declined.Conclusions：Under the high glucose,Baicalin can decrease adhesion molecules.The cause is that Baicalin may inhibit inflammatory response.

关 键 词：黄芩苷 人脐静脉血管内皮细胞株 高糖 粘附分子 

分 类 号：R285.5[医药卫生—中药学]