新型吡啶基吡唑酰胺类化合物的合成  

Synthesis of Novel Pyridyl-pyrazole-5-carboxylic Acid Amide Compounds

作　　者：郑毅[1] 王俊芳[1] 张应鹏[1] 杨云裳[1] 

机构地区：[1]兰州理工大学石油化工学院,兰州730050

出　　处：《应用化学》2010年第9期1105-1107,共3页Chinese Journal of Applied Chemistry

基　　金：甘肃省自然科学基金(3ZS062-B25-017)资助项目

摘　　要：以2,3-二氯吡啶为起始原料,经过肼解、与马来酸二乙酯成环、卤代、氧化和水解得到关键中间体吡啶基吡唑甲酸,然后与二氯亚砜反应生成甲酰氯,最后与各种环氨作用生成吡啶基吡唑甲酰胺类化合物。Key intermediate pyridinyl-1H-pyrazole-5-carboxylic acid was synthesized from the reaction of 2,3-dichloropyridine with hydrazine,which was then treated with diethyl maleate,then esterified through halogenation,oxidation,hydrolysis.Carbonyl chloride was synthesized by dichloro sulfoxide,and pyridinyl-1H-pyrazole-5-carboxylic acid amide compounds were synthesized by carbonyl chloride reacting with corresponding ammonia.

关 键 词：吡啶基吡唑羧酸 酰胺 合成 

分 类 号：O622.5[理学—有机化学]