血管紧张素转换酶基因型与高血压左室肥厚的相关性研究  

Correlation of Polymorphism of Angiotensin Converting Enzyme Genes with Left Ventricular Hypertrophy in Essential Hypertension

作　　者：吴寿领[1] 洪江[1] 李宏芬[1] 冯绍儒 乔德仁[1] 高明[1] 施继红[1] 聂红莲 

机构地区：[1]河北省唐山市开滦医院心内科

出　　处：《高血压杂志》1999年第2期130-132,共3页Chinese Journal of Hypertension

摘　　要：目的研究血管紧张素转换酶（ＡＣＥ）基因型与高血压患者左室肥厚的关系。方法用ＰＣＲ方法分别检测１５１例原发高血压患者ＡＣＥ基因型，并做超声心动图检查，测量左室舒张末径（ＤＬＶｄ）、左室收缩末径（ＳＬＶｄ）、心脏室间隔厚度（ＩＶＳ）及左室后壁厚度（ＬＶＰＷ），计算左室重量（ＬＶＭ）。结果各基因型组中ＤＤ型的ＤＬＶｄ、ＳＬＶｄ、ＩＶＳ、ＬＶＰＷ、ＬＶＭ分别为４９．９±５．６ｍｍ、３０．５±６．５ｍｍ、１１．２±１．６ｍｍ、１１．７±１．５ｍｍ、２５９．５±６２．１ｇ，ＩＤ型组的ＤＬＶｄ、ＳＬＶｄ、ＩＶＳ、ＬＶＰＷ、ＬＶＭ分别为４８．９±５．３ｍｍ、３１．５±５．２ｍｍ、１１．４±１．７ｍｍ、１１．９±１．６ｍｍ、２６１．３±７０．３ｇ，Ｉ型组的ＤＬＶｄ、ＳＬＶｄ、ＩＶＳ、ＬＶＰＷ、ＬＶＭ分别为４８．９±５．５ｍｍ、３１．８±６．５ｍｍ、１１．１±１．９ｍｍ、１１．５±１．８ｍｍ、２５０．８±８２．５ｇ，各基因型组间ＤＬＶｄ、ＳＬＶｄ、ＩＶＳ、ＬＶＰＷ、ＬＶＭ并无显著性差异（Ｐ＞０．０５）。结论国人ＡＣＥ基因型与高血压左室肥厚无关。Aim \ To investigate the correlation of polymorphism of angiotensin converting enzyme genes with left ventricular hypertrophy in essential hypertension.\ Methods \ ACE genotypes were determined by PCR technology in 151 cases of essential hypertension. Diastolic left ventricular diameter (DLVd), systolic left ventricular diameter (SLVd), interseptal ventricular thickness(IVS) and left ventricular posterior wall thickness(LVPW) were measured by using echocardiographer. Left ventricular mass(LVM) was calculated by echocardiographic parameters.\ Results \ DLVd, SLVd, IVS, LVPW and LVM in DD genotype group are 49.95.6 mm,30.560.5 mm,11.21.6 mm,11.71.5 mm and 259.562.1 g respectively. They are 8.95.3 mm, 31.55.2 mm, 11.41.7 mm, 11.91.6 mm and 261.370.3 g in ID group, and 48.95.5 mm, 31.86.5 mm , 11.11.9 mm, 11.51.8 mm and 250.882.5 g in II group. There was no significant difference of DLVd, SLVd, IVS, LVPW and LVM between ID, DD and II genotype groups (P>0.05).\ Conclusion \ No association between ACE gene and left ventricular hypertrophy in essential hypertension could be found.

关 键 词：超声心动图 左室肥厚 高血压 ACE 

分 类 号：R544.102[医药卫生—心血管疾病]