高迁移率蛋白-1水平变化与脓毒症患者死亡率的关系  

Relationship between The Serum Levels of HMGB-1 and The Mortality Rate in Patients with Sepsis

作　　者：马玉东[1] 黎明新[2] 孙宝山[1] 宋岩[1] 

机构地区：[1]沈阳医学院奉天医院ICU,辽宁沈阳110024 [2]沈阳医学院奉天医院检验科,辽宁沈阳110024

出　　处：《沈阳医学院学报》2010年第3期136-137,143,共3页Journal of Shenyang Medical College

基　　金：辽宁省教育厅课题(No.2008727)

摘　　要：目的:研究脓毒症患者血清高迁移率蛋白-1(HMGB-1)水平变化,及其与死亡率的关系。方法:测定48例脓毒症患者血清HMGB-1的变化并记录患者转归。结果:随着治疗时间的增加,死亡组和存活组患者血清HMGB-1水平均逐渐上升,在24 h时,两组患者HMGB-1水平无明显差异;于72 h达高峰,死亡组患者血清HMGB-1水平明显高于存活组患者HMGB-1水平(P<0.01);当患者血清HMGB-1≥100μg/L时,患者的死亡率将明显升高。结论:血清HMGB-1水平变化可以预测脓毒症患者的预后,当患者血清HMGB-1≥100μg/L时,患者的死亡率将明显升高,临床应及早给予干预。Objective：To study the serum levels of high mobility group protein box-1（HMGB-1）in patients with sepsis,and the relationship between the serum HMGB-1 concentration and the mortality rate.Methods：The serum HMGB-1 levels of patients with sepsis were determined.The clinical outcomes in those patients were recored and analysed.Results：Along with treatment time enlongation,the serum HMGB-1 levels of both death group and survival group were increased gradually and peaked at 72 hours after the onset of the disease.There was no significant difference in the serum HMGB-1 levels of these two groups at 24 hours.The serum HMGB-1 levels of death group were much higher than those of survival group（P0.05）.The mortality rate significantly increased when the serum HMGB-1 concentration was higher than 100 μg/L.Conclusion：The serum HMGB-1 levels could be used to predict the prognosis of patients with sepsis.Early clinical intervention should be considered for patients with sepsis in order to reduce the mortality rate in patients with high serum HMGB-1 level.

关 键 词：高迁移率蛋白-1 脓毒症 死亡率 

分 类 号：R631[医药卫生—外科学]