细胞凋亡研究促进新药开发的展望  

ADVANCE IN RESEARCH OF APOPTOSIS IN PROMOTING NEW DRUGS DEVELOPMENT

作　　者：刘俊达[1] 张靖莲[1] 

机构地区：[1]北京医院老年医学研究所

出　　处：《中国新药杂志》1999年第5期298-301,共4页Chinese Journal of New Drugs

摘　　要：细胞凋亡（ａｐｏｐｔｏｓｉｓ，Ａｐｏｐ）是在生理或病理条件下细胞的一种主动死亡方式，是受细胞内基因及细胞外一些因子调控的生物过程。作者阐述了细胞凋亡在衰老、肿瘤、良性前列腺增生症、阿尔茨海默氏病及自身免疫性疾病发病中的作用，并列举某些细胞凋亡调控药物，如反义寡核苷酸、基因治疗、核因子κＢ抑制剂、酪氨酸蛋白激酶抑制剂、一氧化氮抑制剂及细胞凋亡素，并评估它们的效果。Apoptosis is an active event of cell death under physiological or pathological condition,and a biological process modulated by intracellular genes and some extracellular factors.The effect of apoptosis in aging and pathogenesis of tumor,benign prostatic hyperplasia,Alzheimer's disease and some autoimmune diseases were described. Some agents for modulating apoptosis,such as antisense oligonucleotides,gene therapy,NF κB inhibitor,nitric oxide inhibitor,apoptin,and their future development were also introduced with their efficiency evaluated.

关 键 词：细胞凋亡 基因调控因子 衰老抑制剂 新药 

分 类 号：R977.9[医药卫生—药品] R329.28[医药卫生—药学]