早期川芎嗪联合血液灌流治疗急性百草枯中毒对各脏器功能的影响  

Effect of Ligustrazine Injection Combined with Hemoperfusion on Acute Paraquat Poisoning at Early Stage

作　　者：李敬[1] 王岚[1] 王璞[1] 王荣霞[2] 

机构地区：[1]河北医科大学附属哈励逊国际和平医院EICU,河北省衡水市053000 [2]衡水市第二人民医院

出　　处：《中国全科医学》2010年第27期3074-3076,共3页Chinese General Practice

摘　　要：目的探讨川芎嗪注射液联合血液灌流治疗急性百草枯中毒对各脏器功能的影响。方法选择我院ICU 2007年1月—2010年1月收治的急性百草枯中毒患者30例为研究对象,分为常规治疗组和川芎嗪组。常规治疗组给予常规治疗及血液灌流,川芎嗪组为常规治疗组的基础上联合川芎嗪注射液治疗。结果两组患者在性别、年龄、中毒剂量、服药距洗胃时间、急性生理学及慢性健康状况评分系统Ⅱ(APACHE-Ⅱ)评分比较,差异均无统计学意义(P>0.05)。治疗后1周川芎嗪组氧分压(PO2)较常规治疗组明显升高,差异均有统计学意义(P<0.05)。治疗后川芎嗪组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、α-羟丁酸脱氢酶(HBDH)及血肌酐(Cr)较常规治疗组明显降低,差异均有统计学意义(P<0.05)。结论早期应用川芎嗪联合血液灌流可保护百草枯对重要脏器的损害,减轻肺间质纤维化,降低百草枯中毒的并发症。Objective To approach the effects of Ligustrazine injection combined with hemoperfusion on the functions of multiple organs in treatment of acute paraquat poisoning.Methods Totally 30 patients with acute paraquat poisoning who were admitted to ICU of our hospital from January 2007 to January 2010 were divided into trial group and conventional group.Patients in the conventional group were treated with routine therapy and hemoperfusion,and patients in the trial group accepted Ligustrazine injection on the basis of conventional group.Results There were no significant differences between the two groups in gender,age,amount of poisoning,time of medication after gastrolavage,and（APACHE-Ⅱ）score （P0.05）.After one-week treatment the value of PO2 was increased significantly in the trial group than in the conventional group （P0.05）;and the levels of alanine amiotransferase,aspartate aminotransferase,creatine kinase,creatine kinase-MB,α-hydroxybutyrate dehydrogenase,and blood creatinine were significantly decreased in the trial group than in the conventional group （P0.05）.Conclusion At the early stage Ligustrazine injection combined with hemoperfusion can protect major organs from paraquat injury,lessen the degree of pulmonary interstitial fibrosis,and reduce the mortality of paraquat poisoning.

关 键 词：百草枯 中毒 川芎嗪 灌流 

分 类 号：R595.5[医药卫生—内科学]