高血压不同中医肝证患者血脂IL-18变化的观察  

Observation on IL- 18 changes of hypertensive liver syndrome of traditional chinese medicine

作　　者：韦延忠 李天资[2] 梁烨[2] 许晓萍[2] 潘兴寿[2] 黄贵明 凌嘉康 邱菊江 黄连春 黄莺飞 

机构地区：[1]平果县中医院,广西百色531400 [2]右江民族医学院心血管疾病研究所,广西南宁530000

出　　处：《中医临床研究》2010年第16期10-12,共3页Clinical Journal Of Chinese Medicine

基　　金：广西百色市科技厅资助项目,合同编号：百科技0910002.

摘　　要：目的：探讨高血压不同中医肝证患者的病因及其发病机制。方法：对156例高血压肝气郁结和153例高血压肝阳上亢患者进行血脂和白介素-18（IL-18）水平检测，并与139例健康体检者比较。结果：肝阳上亢组其TC，TG，和LDLC均值分别为5．62±1．24（mmol／L）、1．54±1．68（mmol／L）和3．23±1．13（mmol／L），65．1±19．2（pg／ml），较肝气郁结组高（P〈0．01），也较正常对照组高（P〈0．01），肝阳上亢纽的HDLC均值为1．37±0．48（mmol／L）较肝气郁结组低（P〈0．01），也较正常对照组低（P〈0．01）。结论：血脂紊乱和炎症反应参与了中医辨证为肝阳上亢和肝气郁结高血压患者的病理生理过程。不同中医肝证高血压患者均有脂质代谢紊乱，其中肝阳上亢患者血脂水平改变较肝气郁结患者更为显著，提示不同的中医肝证脂质代谢紊乱程度不一样。Objective： To investigate etiological factor and pathogenesis of two types of liver syndrome of traditional chines medicine. Methods： 156 cases of hypertensive stagnation of liver-QI and 153 cases of hypertensive hyperactivity of liver-YANG should be tested the level of blood-fat and interleukin-18 （IL-18）, and be compared to 139 cases who are normal in health examination. Results： The mean TC, TG and LDLC are 5.62± 1.24 （mmol/L）, 1.54± 1.68 （mmol/L） and 3.23± 1.13 （mmol/L）, 65.1 ± 19.2 （pg/ml） respectively in hypertensive stagnation of liver-QI group, which are higher than that of the hyperactivity of liver-YANG group （P〈0.01）, and so is the normal group; the mean HDLC of hyperactivity of liver-YANG group is 1.37±0.48 （mmol/L）, which is lower than that of the hypertensive stagnation of liver-QI group （P〈0.01）, and so is the normal group （P〈0.01）. Conclusion： Both disorder of blood-fat and inflammatory reaction differentiate the pathologic and physiologic process of hypertensive stagnation of liver-QI and hyperactivity of liver-YANG patients. There is lipid metabolic disorder in these types of hypertensive patients of liver syndrome of traditional chines medicine, in which the blood-fat level of the liver-YANG group is higher than that of the liver-QI group, to prompt that different types of liver syndrome of traditional chines medicine differ degree of lipid metabolic disorder.

关 键 词：高血压 中医肝证 血脂 白介素-18 

分 类 号：R259.441[医药卫生—中西医结合]