类风湿性关节炎的治疗进展  

Advance in treatment of rheumatoid arthritis

作　　者：钟路[1] 

机构地区：[1]海南省人民医院肾病研究室,海南海口570311

出　　处：《中国热带医学》2010年第11期1419-1421,共3页China Tropical Medicine

摘　　要：近10年来,生物治疗在类风湿性关节炎中取得了很大的进步,然而这种治疗因其昂贵不良反应大而且需要反复注射而受到很大限制,而基因治疗则避免了这些缺点,选择性高,能稳定作用到靶基因,已在在动物实验中得到证实,但临床实验还处在起步阶段。本文就1,基因转移载体、2,细胞因子转移基因治疗、3,组织修复及组织破坏因子的转基因治疗、4,细胞凋亡基因的转基因治疗;做一个综述,以方便专业医疗工作者了解其进展。Great progress has been made in the last decade in treatment of reumatoid arthritis （RA） by using biological technologies. However, there are several serious limitations of these therapies ,such as the high expense, side-effects, and the requirement for repeated injections. Gene therapy for the treatment of RA is effective and stably on the specific target. Gene transfer vector,transfer cytokine gene therapy,tissue repair and gene therapy,therapy gene transfer for apoptosis gene were discussed in this paper.

关 键 词：类风湿性关节炎 基因治疗 基因转移技术. 

分 类 号：R593.22[医药卫生—内科学]