TNF-α-308位点多态性与中国系统性红斑狼疮相关性的Meta分析  

Correlation between TNF-α Promoter-308A/G Polymorphism and Systemic Lupus Erythematosus in Chinese Populations:A Meta-analysis

作　　者：高香[1] 吕玲[1] 王小钦[2] 

机构地区：[1]复旦大学附属华山医院风湿科,上海200040 [2]复旦大学附属华山医院血液科,上海200040

出　　处：《中国循证医学杂志》2010年第9期1053-1057,共5页Chinese Journal of Evidence-based Medicine

摘　　要：目的评价TNF-α-308位点多态性与中国系统性红斑狼疮的相关性。方法检索PubMed、EBSCO、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库,收集TNF-α-308位点多态性与中国系统性红斑狼疮(SLE)相关性的文献。检索时间为建库至2010年3月。用Meta分析的方法检测基因型AAvs.GG、GAvs.GG、AAvs.GG+GA、GA+AAvs.GG和Avs.G在SLE组与对照组中是否有差异。结果共纳入8篇文献,共有SLE患者731例,健康对照901例。对总体人群进行Meta分析,未发现等位基因A与SLE相关[OR=1.42,95%CI(0.97,2.09),P=0.07];将人群按地域分层,未发现-308A与中国台湾人群SLE相关[OR=1.04,95%CI(0.77,1.40),P=0.82]。基因型AAvs.GG、GAvs.GG、AAvs.GG+GA、GA+AAvs.GG在SLE组与对照组中无显著差异。结论本研究未鉴定出TNF-α-308位点等位基因和基因型与中国SLE相关。Objective To summarize results of the correlation of tumor necrosis factor-α （TNF-α） promoter-308A/G polymorphism with systemic lupus erythematosus （SLE） susceptibility in Chinese populations.Methods We collected all the publications about the correlation between TNF-α promoter-308A/G polymorphism and SLE in Chinese populations by searching PubMed,EBSCO,CBM,CNKI and Wanfang Data before the date of March 20,2010.Meta-analysis was performed for checking the difference between two groups about genotypes such as AA versus GG,GA versus GG,AA versus GG＋GA,GA＋AA versus GG,and A allele versus G allele.Results A total of 8 studies involving 731 SLE patients and 901 healthy people were included.The meta-analysis of total populations showed that,there was no significant correlation between A allele and increased SLE risk （OR=1.42,95%CI 0.97 to 2.09,P=0.07）;the meta-analyses of populations in different regions showed there was no significant correlation of A allele and increased SLE risk in Chinese Taiwan populations （OR=1.04,95%CI 0.77 to 1.40,P=0.82）.Moreover,there was no significant difference between SLE group and control group in the genotypes of AA versus GG,GA versus GG,AA versus GG＋GA,and GA＋AA versus GG.Conclusion This meta-analysis dosen＇t demonstrate the correlation between TNF-α promoter-308A/G polymorphism and SLE in Chinese populations.

关 键 词：META分析 TNF-Α基因 系统性红斑狼疮 基因多态性 中国人群 

分 类 号：R593.241[医药卫生—内科学]