外侧缰核对中缝大核神经元的双向调制作用及中缝大核神经元兴奋抑制转化的规律  

Bi-directional Modulation of Nucleus Lateral Habenula on NRM Neurons and the Regularity of Excitatory-inhibitory Transformation of NRM Neurons

作　　者：刘乡[1] 张守信[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1999年第2期116-121,共6页Acupuncture Research

摘　　要：本工作的目的在于研究连接边缘前脑和中脑的重要结构缓核对ＮＲＭ的调控作用。细胞外记录大鼠ＮＲＭ神经元的放电，电刺激 ＮＬＨ，当强度达 ４Ｖ以上时，观察到刺激中对 ＮＲＭ有兴奋作用，放电增加，而刺激停止以后为抑制作用，使细胞放电减少甚至停止。而且 ＮＬＨ对 ＮＲＭ这种即时兴奋和后抑制双向调制作用，可随刺激强度的增加而增强。但以同样强度系列刺激伏核时，刺激中和刺激停止后均为兴奋作用，故 ＮＬＨ对 ＮＲＭ的这种双相调制作用可能是特异性的。当损毁两侧 ＮＬＨ后， ＮＲＭ神经元放电明显增加，可见 ＮＬＨ对 ＮＲＭ的双向调控作用中以后抑制作用占优势，有紧张性抑制解除的现象。在ＮＲＭ神经元由于损毁ＮＬＨ自发放电明显增加的背景上，刺激Ｓｍ Ⅱ时则不再能兴奋ＲＮＭ神经元，而是使其抑制，再次看到兴奋转化为抑制的规律。The aim of present work was to study how nucleus raphe magnus(NRM) neurons are modulated by the nucleus lateral habenula(NLH), that plays a pivotal role in funnelling information from the limbic forebrain to the limbic midbrain area. Neuron discharges of NRM were recorded extracellularly by glass microelectrode in rats. Electrical stimulation of NLH for 5 see, when its intensity over 4V, could excitate NRM neurons, increasing unit discharges during stimulation, and inhibit the neurons, decreasing discharges after stopping stimulation, besides, the bi-directional modulation of immediate-excitation and post-inhibition of NLH on NRM neurons could be enhanced with the increase of stimulation intensity. But the effects of stimulation of nucleus accumbens(NAc) with the same series of intensities on the same neuron were all excitation during and stopping stimulation. Thus the bi-directional modulation of NLH on NRM neuron may be a specificity. After lesion of bilateral NLH, the discharges of NRM neurons were obviously increased (P < 0. 05 ), showing a tonic inhibition on them to be removed. On the background of discharge increase of NRM neurons after NLH lesion, the excitatory responses of NRM neuron to Sin Ⅱ stimulation were reversed to inhibitory responses. The phenomenon of excitatory-inhibitory change may be a regularity.

关 键 词：外侧缰核 中缝大核 双向调制作用 针刺镇痛 

分 类 号：R245-0[医药卫生—针灸推拿学]