中国东北汉族人群变应性鼻炎患者HLA-DRB1基因多态性分析  

Analysis of HLADRB1 allele polymorphism for patients with allergic rhinitis

作　　者：杨玲[1] 张庆瑞[1] 张平[1] 叶晶[1] 尹璐[1] 

机构地区：[1]解放军第二零二医院变态反应室

出　　处：《中华耳鼻咽喉科杂志》1999年第3期147-149,共3页Chinese Journal of Otorhinolaryngology

摘　　要：目的分析中国东北地区汉族人变应性鼻炎（ａｌｅｒｇｉｃｒｈｉｎｉｔｉｓ，ＡＲ）患者与ＨＬＡ（ｈｕｍａｎｌｅｕｋｏｃｙｔｅＡｓｙｓｔｅｍ）ＤＲＢ１等位基因的关联。方法采用聚合酶链反应序列特异性引物技术对３５例东北汉族变应性鼻炎患者的ＨＬＡＤＲＢ１等位基因进行检测，对照组为同地区９４例健康者。结果统计学分析结果显示患者组ＨＬＡＤＲＢ１０１０１．２和０３０２等位基因比正常对照组明显增高，基因频率分别为１２．８６％（相对危险性为１５．９２，校正Ｐ值＜０．０００４）和５．７１％（相对危险性为１２．００，校正Ｐ值＜０．０５），其它等位基因频率在实验组和对照组之间差异无显著性。结论提示ＨＬＡＤＲＢ１０１０１．２和ＤＲＢ１０３０２等位基因与ＡＲ关联。Objective To analyze the association between allergic rhinitis and HLADRB1 in northeast area of China. MethodsZUsing polymerase chain reaction /sequence specific primers (PCR/SSP) technique, we studied distributive speciality of HLADRB1 alleles in 35 patients with (AR) and 94 healthy controls. Results The statistical results showed that the frequencies of DRB1*0101.2 and DRB1*0302 alleles were significantly higher in AR patients than in those of controls. The frequencies of DRB1*0101,2 and DRB1*0302 were 12.86% (relative risk=15.92 Pc<0.0004) and 5.71% (relative risk=12.00,Pc<0.05) respectively, the other gene frequencies bore no significant difference. ConclusionAR was associated with HLADRB1*0101.2 and DRB1*0302 alleles.

关 键 词：鼻炎 变应性 常年性 MHCⅡ类基因 PCR 

分 类 号：R765.210.2[医药卫生—耳鼻咽喉科]