米非司酮与孕三烯酮用于子宫内膜异位症术后的对比研究  

Comparative study on mifepristone and gestrinone for patients with endometriosis after surgery

作　　者：江世敏[1] 

机构地区：[1]四川省阿坝州小金县人民医院,624200

出　　处：《临床合理用药杂志》2010年第18期46-47,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的对比米非司酮与孕三烯酮用于子宫内膜异位症术后的临床疗效。方法子宫内膜异位症术后患者90例随机分为A组和B组,各45例。A组给予米非司酮治疗,B组给予孕三烯酮治疗,2组均治疗6个月。观察2组治疗后症状缓解情况,测定卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P);同时了解药物不良反应与复发情况。结果 2组完全缓解率、部分缓解率和复发率比较差异无统计学意义(P>0.05);治疗后血清FSH、LH、E2、P水平有所降低,但仅血清P与用药前比较差异有统计学意义(P<0.05);B组阴道出血、体质量增加、转氨酶升高发生率高于A组,差异有统计学意义(P<0.05)。结论米非司酮与孕三烯酮用于子宫内膜异位症术后的临床疗效相近,但米非司酮不良反应较少,是治疗子宫内膜异位症术后患者的较好方法。Objective To compare the clinical effect of mifepristone and gestrinone for patients with endometriosis after surgery.Methods 90 cases of endometriosis patients after surgery were randomly divided into group A and group B,45 cases of each.Group A was given mifepristone treatment,group B received gestrinone treatment,the two groups were treated for 6 months.Observed symptomatic remission after the treatment of the two groups,measured follicle-stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2）,progesterone（P）;Observed adverse drug reactions and recurrence situation at the same time.Results The complete remission rate,partial response rate and relapse rate of the two groups were no significant difference（P0.05）;Serum FSH,LH,E2,P levels decreased after treatment,but only serum P has statistical difference（P0.05）;Group B of vaginal bleeding,weight increase,elevated aminotransferases were higher than these in group A,the differences were statistically significant（P0.05）.Conclusion Mifepristone is similar to gestrinone for endometriosis postoperative clinical efficacy,but less side effects of mifepristone,is an ideal method of treatment for endometriosis patients after surgery.

关 键 词：米非司酮 孕三烯酮 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]