中老年健康人群血尿酸升高机制的探讨  

Study on the mechanism of hyperuricemia among middle and elderly groups.

作　　者：李跃松[1] 浦洪波[1] 武红玉[1] 陈永伟[1] 朱利国[1] 

机构地区：[1]江苏省原子医学研究所附属江原医院检验科,无锡214063

出　　处：《中国综合临床》2010年第9期959-962,共4页Clinical Medicine of China

摘　　要：目的探讨中老年健康人群血尿酸升高的机制。方法对1073例健康体检的中老年高尿酸患者的肾功能、空腹血糖、血脂等各项生化指标与同期1235例血尿酸正常的体检者进行对比分析。结果高尿酸患者的血肌酐、尿素氮、空腹血糖、甘油三酯、总胆固醇各项指标均明显高于正常对照组（男性：t值或t’值分别为7．508、9．484、6．208、7．055、5．097，P均〈0．05；女性：t值或t’值分别为11．221、8．314、5．641、8．328、7．227，P均〈0．05）。年龄分组后显示，男性正常对照组和高尿酸组各年龄组之间在尿素氮、空腹血糖、甘油三酯间差异有统计学意义（对照组：F值分别为3．500、5．607、3．378，P均〈0．05；高尿酸组：F值分别为15．400、5．111、11．143，P均〈0．05），而尿素氮、血肌酐、空腹血糖、甘油三酯的阳性率在各年龄组间有差异（对照组：χ^2值分别为17．112、7．807、17．829、8．433，P均〈0．05；高尿酸组：0值分别为35．587、83．005、41．639、31．466，P均〈0．05），同年龄组间，高尿酸纽尿素氮、血肌酐的平均值和阳性率都高于正常对照组（P均〈0．05），甘油三酯的平均值各年龄组均高于正常对照组（P〈0．05），而阳性率在970岁组差异无统计学意义（P〉0．05）。空腹血糖和总胆固醇在低年龄组平均值和阳性率差异有统计学意义（P均〈0．05），而高年龄组差异无统计学意义（P〉0．05）。女性正常对照组各统计指标在各年龄组间平均值和阳性率差异有统计学意义（尿素氮：F=13．759，χ^2=19．491，P均〈0．05；空腹血糖：F=13．554，χ^2=33．438，P均〈0．05；甘油三酯：F=18．160，0=16．978，P均〈0．05；总胆固醇：F=37．647，χ^2=60．547，P均〈0．05），而高尿酸组只有尿素氮、血肌酐、总胆固醇的平均值和阳性率在各年龄组间有差异（尿素氮：F=5．83Objective To study the mechanism of the hyperuricemia among the middle and elderly populations. Methods Serum uric acid, ereatinine （Cr） , blood urea nitrogen （ BUN ）, fasting gluose （ FG ）, total cholesterol （TC）, triglyceride（ TG ） were detected in 1073 subjects with hyperuricemia and 1235 subjects with normal serum uric acid as control of middle and elder groups. Results The means of Cr, BUN, FG,TG, TC in hyperuricemia were significantly higher than those in the control group,respectively （males： t＇ = 7. 508 ,P 〈 0. 05;t＇ = 9. 484,P 〈 0. 05 ;t =6. 208,P 〈 0. 05 ;t＇ = 7. 055 ,P 〈 0. 05 ;t = 5. 097 ,P 〈 0. 05 ; females; t＇ = 11. 221 ,P 〈 0. 05 ;t＇ = 8. 314, P 〈 0. 05 ; t = 5. 641, P 〈 0. 05 ;t＇ = 8. 328,P 〈 0. 05 ; t = 7. 227, P 〈 0. 05 ）. In males, the mean of the BUN ; FG and TG were significant different among the different age groups （ the control group ： F = 3. 500, P 〈 0. 05 ; F = 5. 607, P 〈 0. 05 ; F = 3. 378, P 〈 0. 05 ; the hyperurieemia group ： F = 15. 400, P 〈 0. 05 ; F = 5.111, P 〈 0. 05 ; F = 11. 143, P 〈 0. 05） ,the positive rate of BUN, Cr, FG and TG were significant different among the different age groups （control group：χ^2 = 17. 112,P 〈0. 05;χ^2 = 7. 807,P 〈0. 05 ;χ^2 = 17. 829,P 〈0. 05; χ^2 = 8.433 ,P 〈0. 05 ; hyperurieemia = χ^2 group：χ^2 35.587,P〈0.05;χ^2=83.005,P〈0.05;χ^2 =41.639,P〈0.05; =31.466,P〈0.05）.Inthe same age group, the mean and the positive rate of BUN and Cr were significantly higher in the hyperuricemia group than in the control group（ P 〈0.05 ）. The mean of TG was significantly higher in every age group of the hyperuricemia group than controls （ P 〈 . 05 ）, but the positive rate had no significant differences in the age group of ≥ 70 years （ P 〉 0. 05 ）. The mean and the positive rate of FG and TC were significant differences in middle age group between the hyperuricemia and the control group （P 〈 0. 05 ）, but were no differences in elder age

关 键 词：高尿酸血症 年龄 健康体检 血脂 

分 类 号：R195[医药卫生—卫生统计学]