基质金属蛋白酶-1、基质金属蛋白酶抑制剂-1与肝纤维化的中医治疗  

THE CHINESE TRADITIONAL TREATMENT OF MMP-1 AND TIMP-1 ON HEPATIC FIBROSIS

作　　者：袁建[1] 杨宇[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《井冈山大学学报（自然科学版）》2010年第5期106-108,117,共4页Journal of Jinggangshan University (Natural Science)

基　　金：四川省中医药管理局科研计划基金项目(2007xs16)

摘　　要：肝纤维化(HF)是慢性肝病向肝硬化发展的必经病理过程。肝纤维化的主要病理机制是组织外基质(ECM)的合成与降解失衡,致ECM在肝内异常大量沉积。基质金属蛋白酶-1(MMP-1)和基质金属蛋白酶抑制剂-1(TIMP-1)对调节肝脏ECM代谢起关键作用。调控MMP-1、TIMP-1以维持ECM在肝内的合成与降解平衡是中医防止和逆转HF的重要措施。Hepatic fibrosis is the essential pathological process of chronic liver disease to liver cirrhosis. The main pathological mechanism of hepatic fibrosis is the imbanlance of synthesis and degradation of extra-cellular matrix which results in the extensive deposition of extra-cellular matrix in the liver exceptionally. Matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are thought to play a key role in regulating extra-cellular matrix in liver. So regulating matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 to make the banlance of synthesis and degradation of extra-cellular matrix in liver is the important measure to prevent and reverse the process of hepatic fibrosis in TCM.

关 键 词：肝纤维化 ECM MMP-1 TIMP-1 

分 类 号：R256.4[医药卫生—中医内科学]