尖锐湿疣组织中COX-2和VEGF表达及微血管密度检测  

Expressions of COX-2 and VEGF in condyloma acuminate and microvessel density test

作　　者：李莉娜[1] 

机构地区：[1]长治医学院病理教研室,山西长治046000

出　　处：《吉林医学》2010年第24期4019-4019,共1页Jilin Medical Journal

摘　　要：目的:探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在尖锐湿疣病变中血管增生的作用。方法:应用免疫组化法分别检测40例尖锐湿疣组织和15例正常对照皮肤组织的石蜡标本中COX-2、VEGF蛋白的表达和微血管密度(MVD)。结果:尖锐湿疣组织的MVD值较正常皮肤对照组织的MVD值显著增高,比较差异有统计学意义(P<0.05),MVD和COX-2、VEGF的表达及COX-2、VEGF两者间均成显著正相关,比较差异有统计学意义(P<0.05)。结论:COX-2和VEGF在CA的血管增生上共同促进了CA的发生,进一步促进了CA生长。抑制COX-2和VEGF的表达可能成为治疗CA的重要手段之一。Objective To investigate the roles of COX-2 and VEGF in angiogenesis of condyloma acuminate（CA）.Methods The expressions of COX-2 and VEGF proteins and microvessel density（MVD）in 40 cases of CA and 15 normal prepuce skins were examined with immunohistochemistry staining.Furthermore.Results Condyloma organizations MVD value than normal skin tissue for control of the MVD was significantly higher（P〈0.05）,MVD and COX-2,VEGF expression and COX-2,VEGF were significantly between the two are positively correlated（P〈0.05）.Conclusion COX-2 and VEGF promoted the pathogenesis of CA together by promoting the growth of microvessel.It may be an important method of CA therapy to suppress the expressions of COX-2 and VEGF.

关 键 词：尖锐湿疣 前列腺素内过氧化物合酶 血管内皮生长因子 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]