血糖控制水平对初诊2型糖尿病患者β细胞功能的影响  

Influence of glucose control onβ-cell function in newly diagnosed type 2 diabetes

作　　者：高贤荣[1] 杜瑞伶[1] 苏群[1] 

机构地区：[1]北京市顺义区医院内分泌科,北京101300

出　　处：《吉林医学》2010年第25期4235-4237,共3页Jilin Medical Journal

摘　　要：目的:探讨血糖控制水平对初诊2型糖尿病患者β细胞功能的影响。方法:102例初诊2型糖尿病患者给予口服降糖药物或胰岛素治疗,根据HbA1c是否≤6.5%分为达标组和未达标组,比较OGTT血糖、C肽、HOMA-β等。结果:与未达标组相比,达标组HOMA-β和△I_(30)/△G_(30)显著上升.差异有统计学意义(P<0.01或<0.05)。两组HOMA-IR无统计学意义(P>0.01)。结论:早期强化降糖治疗可消除初诊2型糖尿病患者高血糖毒性,改善β细胞功能。Objective To evaluate the influence of glucose control on β - cell function in newly diagnosed type 2 diabetes. Method Total 102 newly diagnosed type 2 diabetic patients were treated with insulin or oral hypoglycemie agents,and were divided into two groups ： up - to - the - standard group （ HbA1c ≤6. 5% ） and not up - to - the - standard group （ HbA1 c 〉 6.5% ）. Levels of OGTT - glucose,insulin,C- peptide,and index of β- cell function were detected. Results In up- to- the- standard group, HOMA- β, △I30/ △G30 were markedly increased compared to ）lot- up -to- the -standard group（ P 〈 0.01 ,P 〈 0.05 ）. HOMA -IR showed no significant difference between the two groups（ P 〉 0.05 ）. Conclusion Early glucose- up- to- the -standard therapy could eliminate hyperglycemia toxicity and ameliorate β - cell function in newly diagnosed type 2 diabetic patients.

关 键 词：2型糖尿病 强化治疗 Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]