酒石酸长春瑞滨的合成  

Synthesis of Vinorelbine Tartrate

作　　者：刘素云 阙日明 

机构地区：[1]北京科莱博医药开发有限责任公司,北京102600 [2]上海睿智化学研究有限公司,上海201203

出　　处：《中国医药工业杂志》2010年第9期645-648,共4页Chinese Journal of Pharmaceuticals

摘　　要：长春质碱经间氯过氧苯甲酸氧化、三氟乙酐处理后,再与文多灵反应得到关键中间体脱水长春碱,其9'-位经1-氯代苯并三唑氯代、四氟硼酸银处理缩环后,与酒石酸成盐,制得抗肿瘤药酒石酸长春瑞滨,总收率约12%。Catharanthine was subsequently treated with m-chloroperoxybenzoic acid,trifluoroacetic anhydride,vindoline and NaBH4 to give anhydrovinblastine,which after 9＇-chlortnation was treated with AgBF4,followed by salification of L-tartaric acid to obtain the antitumor agent vinorelbine tartrate with an overall yield of about 12%.

关 键 词：长春瑞滨 长春质碱 文多灵 抗肿瘤药 合成 

分 类 号：R979.19[医药卫生—药品]