COPD骨骼肌功能障碍与PPARα基因多态性关系研究  

A study of relations between PPARα gene polymorphism and skeletal muscle atrophy in patient with COPD

作　　者：龙翔宇[1,2] 傅炜萍[1] 何大川[1] 刘华[3] 张剑青[1] 舒敬奎[1] 戴路明[1] 

机构地区：[1]昆明医学院第一附属医院重症呼吸科,昆明650031 [2]四川省广安市人民医院,638000 [3]昆明医学院第一附属医院检验科,昆明650031

出　　处：《重庆医学》2010年第18期2406-2408,共3页Chongqing medicine

基　　金：云南省科技厅计划资助项目(2008CD011)

摘　　要：目的探讨过氧化物酶体增殖活化受体α(PPARα)基因的5个突变位点rs45550937(C/G)、rs45552534(A/G)、rs45576140(C/G)、rs45528736(A/G)、rs45576734(A/G)与慢性阻塞性肺疾病(COPD)骨骼肌功能障碍(SMD)患者的关系。方法采用多聚酶链反应(PCR)测序的方法,对昆明地区128例COPD患者和64例年龄匹配正常对照者的PPARα的上述5个位点进行分析。结果在正常对照者和COPD患者中PPARα的上述5个位点未发现有突变。结论 PPARα基因上述位点多态性与昆明地区COPD患者SMD无相关性。Objective To investigate the relationship bewteen peroxisome proliferators-activated receptors-α（PPARα） gene five point rs45550937（C/G）,rs45552534（A/G）,rs45576140（C/G）,rs45528736（A/G）,rs45576734（A/G） polymorphism with skeletal muscle atrophy in the patient with chronic obstructive pulmonary disease（COPD）.Methods The PPARα′s five point as presented above were assayed by polymerase chain and sequencing methods between 128 COPD patients and 64 age-matched controls in Kunming.Results Both in COPD group and control group,PPARα′s five point as appeared above were not detected mutation.Conclusion The five location polymorphism of PPARα gene are not associated with skeletal muscle atrophy of COPD in Kunming.

关 键 词：过氧化物酶体增殖活化受体α基因 多态性 慢性阻塞性肺疾病 骨骼肌功能障碍 

分 类 号：R563.9[医药卫生—呼吸系统]