辛伐他汀对高血压患者大动脉弹性和踝臂指数的影响  

The Influence of Simvastatin Therapy on Large Artery Elasticity and ABI in Hypertensive patients

作　　者：张永明[1] 杨剑[2] 

机构地区：[1]杭州师范大学卫生所,浙江杭州310036 [2]浙江省立同德医院,浙江杭州310003

出　　处：《健康研究》2010年第4期262-265,共4页Health Research

摘　　要：目的探讨辛伐他汀对高血压患者大动脉弹性和踝臂指数的影响。方法高血压患者103例,依据血清低密度脂蛋白胆固醇(Low density lipoprotein cholesterin,LDL-C)水平分为胆固醇正常组(n=47)和胆固醇升高组(n=56),观察辛伐他汀(舒降之)(40 mg/d)治疗6月后脉搏波传导速度(Pulse wave velocity,PWV)和踝臂指数(Anklebrachial index,ABI)的改变。结果调脂治疗6月后,胆固醇正常组和胆固醇升高组患者的血清LDL-C水平均显著降低(P<0.01),胆固醇正常组及胆固醇升高组患者动脉的PWV均显著降低(P<0.05)。胆固醇升高组的PWV降低比胆固醇正常组更明显。调脂治疗后胆固醇正常组ABI显著升高(P<0.05),胆固醇升高组ABI也显著升高(P<0.05),其改善程度显著大于胆固醇正常组。结论高血压患者给予积极的调脂治疗不仅可以降低血压,同时可显著改善其大动脉弹性,对外周血管疾病也有有益作用,胆固醇升高的患者获益更大。Objective To explore the effects of intensive cholesterol lowering therapy with simvastatin on the large artery elasticity and ankle brachial index （ABI） in hypertension patients. Methods 103 patients with hypertension were stratified into normal cholesterol group （ n = 47 ） and hypercholesterol group （ n = 56） according to serum low density lipoprotein （LDL）. All patients received oral simvastatin 40 rng/d for six months. Pulse wave velocity （PWV） and anklebrachial index （ABI） were determined before and after the therapy. Results The LDL-C level in both groups wre decreased significantly （（2.12±0.29）vs（1.59±0.28）, （3.43 ±0.81）vs（2.29 ±0.48） mmol/L, P〈0.01）. The PWV in normal cholesterol group and in hypercholesterol group were decreased significantly （ P 〈 0. 05 ）. PWV in hypercholesterol group lowered more significantly than that of normal cholesterol group. AB1 was increased significantly in normal cholesterol group （ （ 1.11 ±0.21 ） vs（ 1.22 ± 0.23 ） , P 〈 0.05 ） and in hypercholesterol group （ （ 1.01 ±0.20） vs （ 1.22 ±0.21 ） , P 〈 0.05 ）. However, the increase were more markedly in hvpercholesterol zrouo than that in normal cholesterol group. Conclusion Intensive cholesterol lowering therapy with simvastatin in hypertension patients for 6 months not only reduced the blood pressure, but also significantly improved their large artery elasticity and simultaneously ameliorated peripheral vascular disease. Hypercholester-olemia patients appear to be improved more pronouncedly by simvastatin than that of normoeholesterolemia.

关 键 词：高血压 辛伐他汀 踝臂指数 

分 类 号：R544.1[医药卫生—心血管疾病]