合肥市某“三甲”医院2009年955例ADR分析  

Analysis of 955 Cases ADR ofATriple-AHospital in 2009 in Hefei

作　　者：王玉山[1] 鲁义东[1] 许杜娟[1] 梅响[2] 

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022 [2]安徽医科大学,安徽合肥230022

出　　处：《抗感染药学》2010年第3期213-215,共3页Anti-infection Pharmacy

摘　　要：目的:分析该院2009年药品ADR发生情况,促进临床合理用药。方法:将收集的955例ADR报告按患者年龄、性别,给药途径及引起ADR的药品种类,涉及器官/系统等临床表现进行分析。结果:955例ADR报告中41～65岁患者占34.76%(322/955),女性多于男性(1.86∶1);静脉滴注50.05%(521/955)和口服给药44.48%(463/955)是引发ADR的主要给药途径;涉及18类药品。ADR排名前10位的药品中应用抗菌药物占87.96%(235/266),主要累及消化系统33.51%(320/955),皮肤及其附件27.96%(267/955)。结论:临床应加强ADR的监测,以确保患者用药安全。Objective：To analyze the adverse drug reaction（ADR）of a triple-A hospital in 2009 and to promote the rational drug use.Methods：A total of 955 ADR case reports collected in 2009 were subjected to a statistical analysis in respect of patients＇age and sex,route of administration,drug categories inducing ADR,the organs or system involved,the clinical manifestations etc..Results：Of the total 955 ADR cases,patients aged 41 to 65 were majority,accounting for 34.76%（322/955）and females were more than males（1.86：1）.The primary cause of ADR was intravenous infusion and oral administration,accounting for 50.05%（521/955）and 44.48%（463/955）respectively;the drugs involved 18 kinds of drugs and antimicrobial agents were 87.96%（235/266）in top ten drug causing ADR.The ADRs manifested dominantly by digestive system,skin rash and pruritus were 33.51%（320/955）and 27.96%（267/955）.Conclusion：ADR monitoring should be strengthened to ensure patient medication safety.

关 键 词：药品不良反应(ADR) 抗菌药物 合理用药 

分 类 号：R969.3[医药卫生—药理学]