沥青工血清ras P21蛋白水平检测  

Detection of Serum ras P21 Level inCTP(Coal Tar Pitch) Exposed Workers

作　　者：王新朝[1] 吴逸明[1] 陈琛[1] 

机构地区：[1]河南医科大学劳动卫生学教研室

出　　处：《工业卫生与职业病》1999年第3期149-151,共3页Industrial Health and Occupational Diseases

基　　金：河南省卫生厅及教委资助

摘　　要：为了解职业性肺癌高发人群沥青工血清ｒａｓＰ２１蛋白水平，用ＷｅｓｔｅｒｎＢｌｏｔｉｎｇ法对２４名沥青工和１２名对照血清Ｐ２１蛋白进行了检测；发现沥青工Ｐ２１均值（３５５８７）明显高于对照（１２７０７）（Ｐ＜００１）；对沥青工按工龄、是否吸烟分组并比较，均未发现组间Ｐ２１的显著性差异。此结果提示，煤焦沥青可使接毒者癌蛋白Ｐ２１水平提高。In order to know the serum P21 levels in CTP exposed workers,who were known as the risk population of occupational lung cancer,the serum levels in 24 exposed workers and 12 control subjects were detected with Western Blotting molecular analysis.The results showed that the mean P21 level(3 558\^7)of the exposed workers was significantly higher than that of the controls(1 270\^7)( P]<0\^01).There were no P21 differences among different working\|ages and between the workers with or without smoking history.It indicated that CTP could cause the increase of P21 oncoprotein level.\;

关 键 词：煤焦沥青 血清 P21蛋白 肺癌 

分 类 号：R446.112[医药卫生—诊断学] R734.201[医药卫生—临床医学]